Mary Lyon Centre, International Facility for Mouse Genetics, at MRC Harwell

玛丽·里昂中心，国际小鼠遗传学设施，MRC Harwell

• 批准号: MC_UP_2201/1
• 负责人: Sara Wells
• 金额: $ 3713.67万
• 依托单位: MRC Harwell Institute
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UP_2201%2F1
• 关键词: Mary; Lyon; Centre; International; Facility

The Mary Lyon Centre at MRC Harwell (MLC) is the UK’s national facility for mouse genetics and the use of mouse models for the study of human disease. The specialised services available for UK researchers include the generation and study of genetically altered mice, and the National Mouse Archive, which allows scientists to deposit mouse strains free of charge for archiving and distribution purposes. The MLC is also the central hub of the MRC National Mouse Genetics Network which brings together experts from around the UK to collaborate and share resources.

位于MRC Harwell（MLC）的玛丽里昂中心是英国国家级的小鼠遗传学和小鼠模型用于人类疾病研究的机构。英国研究人员可获得的专门服务包括基因改变小鼠的产生和研究，以及国家小鼠档案馆，该档案馆允许科学家免费存款小鼠品系，以供存档和分发。MLC也是MRC国家小鼠遗传学网络的中心枢纽，该网络汇集了来自英国各地的专家，进行合作和共享资源。

项目成果

Hypercalcaemic mice harbouring a germline ablation of G-protein subunit alpha-11 have anaemia that is corrected by treatment with erythropoietin

携带 G 蛋白亚基 α-11 种系消融的高钙血症小鼠患有贫血，可通过促红细胞生成素治疗来纠正

• DOI: 10.1530/endoabs.86.oc1.2
• 发表时间: 2022
• 期刊: Endocrine Abstracts
• 作者: Hannan F

Presenting the genotyping services at the Mary Lyon Centre at MRC Harwell; a high-throughput mouse genotyping pipeline

在 MRC Harwell 的玛丽里昂中心展示基因分型服务；

• 发表时间: 2022
• 期刊: Transgenic Research
• 影响因子: 3
• 作者: Caulder A

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.

• DOI: 10.1186/s12915-022-01475-0
• 发表时间: 2023-02-03
• 期刊: BMC BIOLOGY
• 影响因子: 5.4
• 作者: Chee, Justine;Lanoue, Louise;Clary, Dave L.;Higgins, Kendall;Bower, Lynette;Flenniken, Ann;Guo, Ruolin;Adams, David;Bosch, Fatima;Braun, Robert E.;Brown, Steve D. M.;Chin, H. -J. Genie;Dickinson, Mary;Hsu, Chih-Wei;Dobbie, Michael;Gao, Xiang;Galande, Sanjeev;Grobler, Anne;Heaney, Jason;Herault, Yann;de Angelis, Martin Hrabe;Mammano, Fabio;Nutter, Lauryl M. J.;Parkinson, Helen;Qin, Chuan;Shiroishi, Toshi;Sedlacek, Radislav;Seong, J-K;Xu, Ying;Brooks, Brian;McKerlie, Colin;Lloyd, K. C. Kent;Westerberg, Henrik;Moshiri, Ala
• 通讯作者: Moshiri, Ala

Mendelian gene identification through mouse embryo viability screening.

• DOI: 10.1186/s13073-022-01118-7
• 发表时间: 2022-10-13
• 期刊: Genome medicine
• 影响因子: 12.3

TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.

TMEM161B 调节发育中的中枢神经系统中的大脑皮质回旋、Sonic Hedgehog 信号传导和纤毛结构。

• DOI: 10.1073/pnas.2209964120
• 发表时间: 2023-01-24
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Akula, Shyam K.;Marciano, Jack H.;Lim, Youngshin;Exposito-Alonso, David;Hylton, Norma K.;Hwang, Grace H.;Neil, Jennifer E.;Dominado, Nicole;Bunton-Stasyshyn, Rosie K.;Song, Janet H. T.;Talukdar, Maya;Schmid, Aloisia;Teboul, Lydia;Mo, Alisa;Shin, Taehwan;Finander, Benjamin;Beck, Samantha G.;Yeh, Rebecca C.;Otani, Aoi;Qian, Xuyu;DeGennaro, Ellen M.;Alkuraya, Fowzan S.;Maddirevula, Sateesh;Cascino, Gregory D.;Giannini, Caterina;Undiagnosed Diseases Network, Lindsay C.;Burrage, Lindsay C.;Rosenfield, Jill A.;Ketkar, Shamika;Clark, Gary D.;Bacino, Carlos;Lewis, Richard A.;Segal, Rosalind A.;Bazan, J. Fernando;Smith, Kelly A.;Golden, Jeffrey A.;Cho, Ginam;Walsh, Christopher A.
• 通讯作者: Walsh, Christopher A.