Novel strategies to improve the effectiveness of radiation and targeted therapies in lung cancer

提高肺癌放射和靶向治疗有效性的新策略

• 批准号: MC_UU_00001/6
• 负责人: Anderson Ryan
• 金额: $ 321.74万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00001%2F6
• 关键词: Novel; strategies; improve; effectiveness; radiation

The majority of patients with cancer will receive radiotherapy at some time during the course of their treatment. The effectiveness of radiotherapy is dependent on the dose that can be delivered, but this is limited by normal tissue toxicity. In this programme of work, we aim to identify novel approaches to improve the effectiveness of radiation, while limiting the effects on normal tissue, with a focus on lung cancer.

大多数癌症患者在治疗过程中会接受放射治疗。放射治疗的有效性取决于可以输送的剂量，但这受到正常组织毒性的限制。在这项工作计划中，我们的目标是确定新的方法来提高辐射的有效性，同时限制对正常组织的影响，重点是肺癌。

项目成果

The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non-Small Cell Lung Cancer.

• DOI: 10.1158/1078-0432.ccr-16-3216
• 发表时间: 2017-09-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Cascone T;Xu L;Lin HY;Liu W;Tran HT;Liu Y;Howells K;Haddad V;Hanrahan E;Nilsson MB;Cortez MA;Giri U;Kadara H;Saigal B;Park YY;Peng W;Lee JS;Ryan AJ;Jüergensmeier JM;Herbst RS;Wang J;Langley RR;Wistuba II;Lee JJ;Heymach JV
• 通讯作者: Heymach JV

The effects of radiation therapy on the macrophage response in cancer.

• DOI: 10.3389/fonc.2022.1020606
• 发表时间: 2022
• 期刊: Frontiers in oncology
• 影响因子: 4.7

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.

• DOI: 10.1038/s41418-020-00655-1
• 发表时间: 2021-04
• 期刊: Cell death and differentiation
• 影响因子: 12.4
• 作者: Herbert KJ;Puliyadi R;Prevo R;Rodriguez-Berriguete G;Ryan A;Ramadan K;Higgins GS
• 通讯作者: Higgins GS

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

• DOI: 10.1101/2023.01.10.521547
• 发表时间: 2023-01
• 期刊: bioRxiv
• 作者: Callum Beach;Dave MacLean;D. Majorova;S. Melemenidis;Dhanya K. Nambiar;Ryan K. Kim;Gabriel N. Valbuena;S. Guglietta;C. Krieg;Damavandi Mahnaz Darvish;Tatsuya Suwa;A. Easton;E. Domingo;E. Moon;D. Jiang;Yanyan Jiang;A. Koong;T. Woodruff;E. Graves;Timothy S. Maughan;S. J. Buczacki;M. Stucki;Q. Le;S. Leedham;A. Giaccia;M. Olcina

Abstract B30: Novel targets for combination therapy in EGFR mutated NSCLC

摘要 B30：EGFR 突变 NSCLC 联合治疗的新靶点

• DOI: 10.1158/1538-8514.synthleth-b30
• 发表时间: 2017
• 期刊: Molecular Cancer Therapeutics
• 影响因子: 5.7
• 作者: Drobnitzky N