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Evaluating new healthcare technologies in cancer

Evaluating new healthcare technologies in cancer
评估癌症领域的新医疗保健技术
批准号:
MC_UU_00004/01
负责人:
Mahesh Parmar
金额:
$660.8万
依托单位:
依托单位国家:
英国
项目类别:
Intramural
财政年份:
2021
资助国家:
英国
项目状态:
未结题
起止时间:
2021 至 --

项目摘要

项目成果

Mahesh Parmar的其他基金

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中文摘要
翻译
我们的目标是减少癌症死亡和与癌症治疗相关的副作用。我们设计临床试验和其他研究研究,同时测试几种新方法。这加快了对新疗法的评估。在这个节目中,我们把重点放在新的科学发展上。特别是针对具有特定遗传标记的癌症的新药,以及防止癌症血管发展的药物。癌症需要新的血管来生存和生长。我们还在测试新的免疫肿瘤学药物。这些药物有助于人体免疫系统杀死癌细胞。我们还将测试人工智能等其他新技术,以改善癌症治疗。人工智能使用计算机的能力来完成通常需要人工输入的任务。例如,放射治疗(x射线治疗)可以用来治愈癌症。但计划治疗是一个复杂而耗时的过程。重要的是,放射治疗只针对癌症,而不是伤害癌症附近的健康组织。使用计算机来加快这一过程可能会让更多的患者更快地得到治疗。这可以在世界各国使用。在我们的研究中,我们收集参与者的血液样本,并与实验室科学家和行业合作伙伴合作,提供更多关于癌症发展和生长的知识。在可能的情况下,我们会在未来的研究中使用这些信息。
英文摘要
Our aim is to reduce cancer deaths and the side effects associated with cancer treatments. We design clinical trials and other research studies that test several new approaches at the same time. This speeds up the evaluation of new therapies. In this programme we focus on new scientific developments. In particular new drugs that target cancers that have specific genetic markers, as well as drugs that prevent a cancer’s blood vessels developing. Cancers need new blood vessels to survive and grow. We are also testing the new immuno-oncology drugs. These drugs help the bodies’ immune system kill cancer cells. We will also test other new technologies such as artificial intelligence to improve cancer treatments. Artificial intelligence uses a computer’s power to do tasks that normally require human input. For example radiotherapy (x-ray treatment) can be used to cure cancers. But it is a complex and time consuming process to plan the treatment. It is important that the radiotherapy only targets the cancer and doesn’t harm healthy tissue near the cancer. Using a computer to speed up this process would potentially allow many more patients to be treated sooner. This could be used in countries all over the world. In our studies we collect blood samples from participants and work with laboratory scientists and industry partners to provide more knowledge about how cancers develop and grow. Where possible we use this information in our future studies.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/s0140-6736(21)02437-5
发表时间: 2022-01-29
期刊: Lancet (London, England)
影响因子: --
作者: [Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND, Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators]
通讯作者: Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
DOI: 10.1001/jamaoncol.2020.7857
发表时间: 2021-04-01
期刊: JAMA oncology
影响因子: 28.4
作者: [Ali A, Hoyle A, Haran ÁM, Brawley CD, Cook A, Amos C, Calvert J, Douis H, Mason MD, Dearnaley D, Attard G, Gillessen S, Parmar MKB, Parker CC, Sydes MR, James ND, Clarke NW]
通讯作者: Clarke NW
DOI: 10.1186/s13058-021-01484-x
发表时间: 2022-01-04
期刊: Breast cancer research : BCR
影响因子: --
作者: [Ahearn TU, Zhang H, Michailidou K, Milne RL, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Augustinsson A, Baten A, Becher H, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H, Brenner H, Brooks-Wilson A, Brüning T, Burwinkel B, Buys SS, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Chenevix-Trench G, Clarke CL, NBCS Collaborators, Collée JM, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dörk T, Dwek M, Eccles DM, Evans DG, Fasching PA, Figueroa J, Floris G, Gago-Dominguez M, Gapstur SM, García-Sáenz JA, Gaudet MM, Giles GG, Goldberg MS, González-Neira A, Alnæs GIG, Grip M, Guénel P, Haiman CA, Hall P, Hamann U, Harkness EF, Heemskerk-Gerritsen BAM, Holleczek B, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, ABCTB Investigators, kConFab/AOCS Investigators, Jakimovska M, Jakubowska A, John EM, Jones ME, Jung A, Kaaks R, Kauppila S, Keeman R, Khusnutdinova E, Kitahara CM, Ko YD, Koutros S, Kristensen VN, Krüger U, Kubelka-Sabit K, Kurian AW, Kyriacou K, Lambrechts D, Lee DG, Lindblom A, Linet M, Lissowska J, Llaneza A, Lo WY, MacInnis RJ, Mannermaa A, Manoochehri M, Margolin S, Martinez ME, McLean C, Meindl A, Menon U, Nevanlinna H, Newman WG, Nodora J, Offit K, Olsson H, Orr N, Park-Simon TW, Patel AV, Peto J, Pita G, Plaseska-Karanfilska D, Prentice R, Punie K, Pylkäs K, Radice P, Rennert G, Romero A, Rüdiger T, Saloustros E, Sampson S, Sandler DP, Sawyer EJ, Schmutzler RK, Schoemaker MJ, Schöttker B, Sherman ME, Shu XO, Smichkoska S, Southey MC, Spinelli JJ, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Teras LR, Terry MB, Torres D, Troester MA, Vachon CM, van Deurzen CHM, van Veen EM, Wagner P, Weinberg CR, Wendt C, Wesseling J, Winqvist R, Wolk A, Yang XR, Zheng W, Couch FJ, Simard J, Kraft P, Easton DF, Pharoah PDP, Schmidt MK, García-Closas M, Chatterjee N]
通讯作者: Chatterjee N
DOI: 10.1200/jco.21.01436
发表时间: 2021-11-20
期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子: --
作者: [Adams RA, Fisher DJ, Graham J, Seligmann JF, Seymour M, Kaplan R, Yates E, Parmar M, Richman SD, Quirke P, Butler R, Brown E, Collinson F, Falk S, Wasan H, Shiu KK, Middleton G, Samuel L, Wilson RH, Brown LC, Maughan TS, FOCUS4 Trial Investigators]
通讯作者: FOCUS4 Trial Investigators
Developing Existing Healthcare Technologies to Deliver More Affordable and Effective Cancer Care
  • 批准号:
    MC_UU_00004/02
  • 项目类别:
    Intramural
  • 资助金额:
    $566.51万
  • 财政年份:
    2021
  • 负责人:
    Mahesh Parmar
  • 依托单位:
Renewal of the Network of Hubs for Trials Methodology Research.
  • 批准号:
    MR/L004933/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $430.81万
  • 财政年份:
    2014
  • 负责人:
    Mahesh Parmar
  • 依托单位:
MRC Clinical Trials Unit as the London Hub for Trials Methodology Research
  • 批准号:
    MC_EX_G0800814
  • 项目类别:
    Research Grant
  • 资助金额:
    $248.19万
  • 财政年份:
    2008
  • 负责人:
    Mahesh Parmar
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Prison-based Naloxone-on-release RCT to reduce drugs-related deaths
  • 批准号:
    MC_EX_G0800012
  • 项目类别:
    Research Grant
  • 资助金额:
    $76.63万
  • 财政年份:
    2008
  • 负责人:
    Mahesh Parmar
  • 依托单位:
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脊髓新鉴定SNAPR神经元相关环路介导SCS电刺激抑制恶性瘙痒
  • 批准号:
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  • 项目类别:
    面上项目
  • 资助金额:
    48.00万元
  • 批准年份:
    2023
  • 负责人:
    焦英甫
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tau轻子衰变与新物理模型唯象研究
  • 批准号:
    11005033
  • 项目类别:
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  • 资助金额:
    18.0万元
  • 批准年份:
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  • 负责人:
    李文君
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HIV gp41的NHR区新靶点的确证及高效干预
强子对撞机上新物理信号的多轻子末态研究
  • 批准号:
    10675110
  • 项目类别:
    面上项目
  • 资助金额:
    36.0万元
  • 批准年份:
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    蒋一
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