Epigenetic programming of metabolic health across the life-course

整个生命过程中代谢健康的表观遗传编程

• 批准号: MC_UU_00014/4
• 负责人: Miguel Constancia
• 金额: $ 222.19万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00014%2F4
• 关键词: Epigenetic; programming; metabolic; health; across

We aim to understand why babies who are exposed to a poor diet in the womb are more likely to develop type 2 diabetes or become obese as adults. Obesity and associated conditions like type 2 diabetes are major health problems in the UK and western countries, influencing both quality and quantity of life. Approximately one third of the adult population in the UK are obese and over 4 million people in the UK are affected by diabetes. We know that how well a baby is nourished in the womb is one factor that influences how likely they are to develop type 2 diabetes and obesity as adults. Therefore, it is very important to understand how early diet has such effects as this may help us develop new medicines for these common conditions. We know that one way in which a poor diet during early life impacts on health is through “epigenetic” processes. This is the way the environment controls which parts of DNA are used to make proteins and therefore how well a cell works. Recent advances in genome research allow us to look at the epigenetic regulation of all the genes in our DNA (~22,000). In this project we will use these technological advances to identify faulty genes that cause metabolic diseases because of poor early diet.

我们的目标是了解为什么在子宫内暴露于不良饮食的婴儿更容易患2型糖尿病或成年后变得肥胖。肥胖和相关疾病如2型糖尿病是英国和西方国家的主要健康问题，影响生活质量和数量。在英国，大约三分之一的成年人是肥胖的，超过400万人患有糖尿病。我们知道，婴儿在子宫内的营养状况是影响他们成年后患2型糖尿病和肥胖的可能性的一个因素。因此，了解早期饮食如何产生这种影响非常重要，因为这可能有助于我们开发针对这些常见疾病的新药。我们知道，生命早期不良饮食影响健康的一种方式是通过“表观遗传”过程。这是环境控制DNA的哪些部分用于制造蛋白质的方式，从而控制细胞的工作方式。基因组研究的最新进展使我们能够看到我们DNA中所有基因的表观遗传调控（约22，000）。在这个项目中，我们将利用这些技术进步来识别由于早期饮食不良而导致代谢疾病的错误基因。

项目成果

The early life environment influences trajectory of post-partum weight loss

早期生活环境影响产后减肥轨迹

• DOI: 10.17863/cam.35742
• 发表时间: 2019
• 作者: Aiken C

Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.

慢性胎儿缺氧会破坏下一代成年雌性大鼠的围孕期环境。

• DOI: 10.1113/jp277431
• 发表时间: 2019
• 期刊: The Journal of physiology
• 作者: Aiken CE

Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.

• DOI: 10.1038/s43856-023-00429-z
• 发表时间: 2024-01-22
• 期刊: COMMUNICATIONS MEDICINE
• 作者: Ahmad, Abrar;Lim, Lee-Ling;Morieri, Mario Luca;Tam, Claudia Ha-Ting;Cheng, Feifei;Chikowore, Tinashe;Dudenhoffer-Pfeifer, Monika;Fitipaldi, Hugo;Huang, Chuiguo;Kanbour, Sarah;Sarkar, Sudipa;Koivula, Robert Wilhelm;Motala, Ayesha A;Tye, Sok Cin;Yu, Gechang;Zhang, Yingchai;Provenzano, Michele;Sherifali, Diana;de Souza, Russell J;Tobias, Deirdre Kay;Gomez, Maria F;Ma, Ronald C W;Mathioudakis, Nestoras
• 通讯作者: Mathioudakis, Nestoras

Early life environment influences the trajectory of post-partum weight loss in adult female rats.

早期生活环境影响成年雌性大鼠产后体重减轻的轨迹。

• DOI: 10.1016/j.rbmo.2018.12.002
• 发表时间: 2019
• 期刊: Reproductive biomedicine online
• 影响因子: 4
• 作者: Aiken CE

Assaying Reproductive Capacity in Female Rodents.

测定雌性啮齿动物的生殖能力。

• DOI: 10.1007/978-1-4939-8994-2_15
• 发表时间: 2019
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Aiken CE