Epigenetic programming of metabolic health across the life-course
整个生命过程中代谢健康的表观遗传编程
基本信息
- 批准号:MC_UU_00014/4
- 负责人:
- 金额:$ 222.19万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Intramural
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We aim to understand why babies who are exposed to a poor diet in the womb are more likely to develop type 2 diabetes or become obese as adults. Obesity and associated conditions like type 2 diabetes are major health problems in the UK and western countries, influencing both quality and quantity of life. Approximately one third of the adult population in the UK are obese and over 4 million people in the UK are affected by diabetes. We know that how well a baby is nourished in the womb is one factor that influences how likely they are to develop type 2 diabetes and obesity as adults. Therefore, it is very important to understand how early diet has such effects as this may help us develop new medicines for these common conditions. We know that one way in which a poor diet during early life impacts on health is through “epigenetic” processes. This is the way the environment controls which parts of DNA are used to make proteins and therefore how well a cell works. Recent advances in genome research allow us to look at the epigenetic regulation of all the genes in our DNA (~22,000). In this project we will use these technological advances to identify faulty genes that cause metabolic diseases because of poor early diet.
我们的目标是了解为什么在子宫内暴露于不良饮食的婴儿更容易患2型糖尿病或成年后变得肥胖。肥胖和相关疾病如2型糖尿病是英国和西方国家的主要健康问题,影响生活质量和数量。在英国,大约三分之一的成年人是肥胖的,超过400万人患有糖尿病。我们知道,婴儿在子宫内的营养状况是影响他们成年后患2型糖尿病和肥胖的可能性的一个因素。因此,了解早期饮食如何产生这种影响非常重要,因为这可能有助于我们开发针对这些常见疾病的新药。我们知道,生命早期不良饮食影响健康的一种方式是通过“表观遗传”过程。这是环境控制DNA的哪些部分用于制造蛋白质的方式,从而控制细胞的工作方式。基因组研究的最新进展使我们能够看到我们DNA中所有基因的表观遗传调控(约22,000)。在这个项目中,我们将利用这些技术进步来识别由于早期饮食不良而导致代谢疾病的错误基因。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The early life environment influences trajectory of post-partum weight loss
早期生活环境影响产后减肥轨迹
- DOI:10.17863/cam.35742
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Aiken C
- 通讯作者:Aiken C
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
慢性胎儿缺氧会破坏下一代成年雌性大鼠的围孕期环境。
- DOI:10.1113/jp277431
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Aiken CE
- 通讯作者:Aiken CE
Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.
- DOI:10.1038/s43856-023-00429-z
- 发表时间:2024-01-22
- 期刊:
- 影响因子:0
- 作者:Ahmad, Abrar;Lim, Lee-Ling;Morieri, Mario Luca;Tam, Claudia Ha-Ting;Cheng, Feifei;Chikowore, Tinashe;Dudenhoffer-Pfeifer, Monika;Fitipaldi, Hugo;Huang, Chuiguo;Kanbour, Sarah;Sarkar, Sudipa;Koivula, Robert Wilhelm;Motala, Ayesha A;Tye, Sok Cin;Yu, Gechang;Zhang, Yingchai;Provenzano, Michele;Sherifali, Diana;de Souza, Russell J;Tobias, Deirdre Kay;Gomez, Maria F;Ma, Ronald C W;Mathioudakis, Nestoras
- 通讯作者:Mathioudakis, Nestoras
Early life environment influences the trajectory of post-partum weight loss in adult female rats.
早期生活环境影响成年雌性大鼠产后体重减轻的轨迹。
- DOI:10.1016/j.rbmo.2018.12.002
- 发表时间:2019
- 期刊:
- 影响因子:4
- 作者:Aiken CE
- 通讯作者:Aiken CE
Assaying Reproductive Capacity in Female Rodents.
测定雌性啮齿动物的生殖能力。
- DOI:10.1007/978-1-4939-8994-2_15
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Aiken CE
- 通讯作者:Aiken CE
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Miguel Constancia其他文献
Non-CpG methylation in the placenta
- DOI:
10.1016/j.placenta.2023.07.123 - 发表时间:
2023-09-07 - 期刊:
- 影响因子:
- 作者:
Cherlyn Tan;Sungsam Gong;Stephen Charnock-Jones;Gordon C.S. Smith;Russell Hamilton;Miguel Constancia - 通讯作者:
Miguel Constancia
Placental endocrine malfunction programs ovarian defects in female murine offspring
- DOI:
10.1016/j.placenta.2019.06.081 - 发表时间:
2019-08-01 - 期刊:
- 影响因子:
- 作者:
Hannah Yong Yong;Sijia Yao;Jorge Lopez-Tello;Efthimia Christoforou;Ionel Sandovici;Miguel Constancia;Amanda Sferruzzi-Perri - 通讯作者:
Amanda Sferruzzi-Perri
Making sense or antisense?
有意义还是无意义?
- DOI:
10.1038/39461 - 发表时间:
1997-10-16 - 期刊:
- 影响因子:48.500
- 作者:
Wolf Reik;Miguel Constancia - 通讯作者:
Miguel Constancia
The role of the phosphoinositol kinase (PI3K) p110α in regulating placental phenotype and fetal growth
- DOI:
10.1016/j.placenta.2014.06.087 - 发表时间:
2014-09-01 - 期刊:
- 影响因子:
- 作者:
Amanda Sferruzzi-Perri;Jaspreet Khaira;Abigail Fowden;Miguel Constancia - 通讯作者:
Miguel Constancia
The role of the embryonic phosphoinositol kinase (PI3K) p110α in regulating placental phenotype and fetal growth
- DOI:
10.1016/j.placenta.2015.07.243 - 发表时间:
2015-09-01 - 期刊:
- 影响因子:
- 作者:
Amanda Sferruzzi-Perri;Ionel Sandovici;Abigail Fowden;Miguel Constancia - 通讯作者:
Miguel Constancia
Miguel Constancia的其他文献
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{{ truncateString('Miguel Constancia', 18)}}的其他基金
The function of the imprinted microRNA-483 in growth, metabolism and cancer
印迹microRNA-483在生长、代谢和癌症中的功能
- 批准号:
MR/J001562/1 - 财政年份:2012
- 资助金额:
$ 222.19万 - 项目类别:
Research Grant
Physiological roles of System A amino acid transporter in fetal growth and development
系统A氨基酸转运蛋白在胎儿生长发育中的生理作用
- 批准号:
BB/I014594/1 - 财政年份:2011
- 资助金额:
$ 222.19万 - 项目类别:
Research Grant
Role of the imprinted Igf2 gene in pancreatic development and function
印记 Igf2 基因在胰腺发育和功能中的作用
- 批准号:
BB/H003312/1 - 财政年份:2009
- 资助金额:
$ 222.19万 - 项目类别:
Research Grant
BBSRC David Phillips Fellowship: Role or imprinted nutrient transporters in fetal growth and development
BBSRC David Phillips 奖学金:胎儿生长发育中的作用或印记营养转运蛋白
- 批准号:
BB/B50118X/2 - 财政年份:2007
- 资助金额:
$ 222.19万 - 项目类别:
Research Grant
Epigenetic regulation of gene expression as a mechanism of nutritional programming and developmental origins of health and disease
基因表达的表观遗传调控作为营养规划和健康与疾病发育起源的机制
- 批准号:
BB/D01235X/2 - 财政年份:2007
- 资助金额:
$ 222.19万 - 项目类别:
Research Grant
Epigenetic regulation of gene expression as a mechanism of nutritional programming and developmental origins of health and disease
基因表达的表观遗传调控作为营养规划和健康与疾病发育起源的机制
- 批准号:
BB/D01235X/1 - 财政年份:2006
- 资助金额:
$ 222.19万 - 项目类别:
Research Grant
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调节组织驻留巨噬细胞谱系的表观遗传编程以影响 HIV-1 感染、维持和持久性。
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