Determining the contribution of peripheral immune complement signalling in the progression of motor neuron disease

确定外周免疫补体信号在运动神经元疾病进展中的作用

• 批准号: nhmrc : 1082271
• 负责人: A/Pr Marc Ruitenberg
• 金额: $ 66.74万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-contribution-peripheral-neuron-disease/518865
• 关键词: Determining; contribution; peripheral; immune; complement

Motor neuron disease (MND) is a debilitating and lethal neurodegenerative disease, which has no effective treatment. We propose that an overactive immune system is a major contributing factor in this disease. To test this, we will examine immune pathways in patients suffering from MND, and will test a novel immune-modulatory drug in animal models of MND. We hope to identify new therapeutic avenues to slow disease progression, and improve the quality of life in patients diagnosed with MND.

运动神经元病是一种致死性神经退行性疾病，目前尚无有效的治疗方法。我们认为，过度活跃的免疫系统是这种疾病的一个主要因素。为了验证这一点，我们将研究MND患者的免疫途径，并将在MND动物模型中测试一种新型免疫调节药物。我们希望找到新的治疗方法来减缓疾病进展，并改善诊断为MND的患者的生活质量。