Central Nervous System Dendritic Cells – Guilty or Not Guilty?

中枢神经系统树突状细胞——有罪还是无罪？

• 批准号: nhmrc : 1069979
• 负责人: A/Pr Marc Ruitenberg
• 金额: $ 32.11万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/central-nervous-dendritic-guilty-guilty/455418
• 关键词: Central; Nervous; System; Dendritic; Cells

The central nervous system although structurally and functionally unique, must be able to mount protective immunological responses. However, breakdown in local and central immunoregulatory processes can lead to clinically disabling inflammatory conditions such as uveitis and multiple sclerosis. This project will investigate the role of Dendritic cells in models of autoimmune diseases affecting the eye and brain. The data will greatly aid our ability to design new immunotherapies to treat these blinding and crippling diseases.

中枢神经系统虽然结构和功能独特，但必须能够产生保护性免疫反应。然而，局部和中枢免疫调节过程的破坏可导致临床上致残的炎性病症，如葡萄膜炎和多发性硬化症。该项目将研究树突状细胞在影响眼睛和大脑的自身免疫性疾病模型中的作用。这些数据将极大地帮助我们设计新的免疫疗法来治疗这些致盲和致残性疾病。