BIOLOGY AND RECEPTOR SIGNALLING OF TRANSFORMING GROWTH FACTOR-BETA
BIOLOGY AND RECEPTOR SIGNALLING OF TRANSFORMING GROWTH FACTOR-BETA
批准号:
5201457
负责人:
A B ROBERTS
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
在哺乳动物中表达的三种tgf - β亚型具有功能
英文摘要
The three isoforms of TGF-beta expressed in mammals are functionally
interchangeable in most in vitro assay systems, but they have distinctive
activities on certain cells. To identify specific functional regions of
the TGF-betas as well as to identify receptor components critical for
TGF-beta action, we are utilizing colon carcinoma cells where the
activities of TGF-beta1 on inhibition of growth are several hundred-fold
more potent than that of TGF-beta2. To define specific regions of the
TGF-beta molecule responsible for these differences in activities, we
developed a system for expression and purification of recombinant
TGF-betas engineered to have either mutations or substitutions of
homologous regions of different isoforms, based on the 3-dimensional
structure of TGF-beta. Using colorectal carcinoma cells which show
selectivity for TGF-beta 1 and 3, we have identified another region of
the molecule (amino acids 69-73) which may be involved in
isoform-specific receptor binding. We have also demonstrated, using
assays which measure in vitro binding to the soluble TGF-beta type II and
III receptors and to the TGF-beta latency-associated protein (LAP),
specific regions of the ligands which interact with these proteins. In
a related aspect of this problem, we are attempting to characterize the
expression of TGF-beta receptors on the colon carcinoma cells and to
identify possible down-stream signalling intermediates. These studies
are important both in identifying the specific elements of the receptor
binding system which mediate isoform-specific effects, and in identifying
putative signalling intermediates, the deletion or mutation of which
would result in loss of TGF-beta responsiveness. It is proposed that
such intermediates will have tumor-suppressor-like activity.
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会议论文
STUDY OF MICE IN WHICH THE TGF BETA GENE HAS BEEN DISRUPTED
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批准号:2463689
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
STUDY OF MICE IN WHICH THE TGF BETA 1 GENE HAS BEEN DISRUPTED
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批准号:3752781
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
MECHANISM OF ACTION OF TYPE BETA TRANSFORMING GROWTH FACTOR
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批准号:4692310
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
NOVEL CHEMOPREVENTIVE AGENTS IN EXPERIMENTAL MAMMARY CARCINOGENESIS
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批准号:6100875
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND MOLECULAR BIOLOGY OF TRANSFORMING GROWTH FACTOR-BETA
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批准号:3853409
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND MOLECULAR BIOLOGY OF TRANSFORMING GROWTH FACTOR-BETA
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批准号:3916749
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND MOLECULAR BIOLOGY OF TRANSFORMING GROWTH FACTOR-BETA
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批准号:3838326
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
STRUCTURE/FUNCTION AND SIGNAL TRANSDUCTION PATHWAYS OF TGF BETA
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批准号:6160869
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
NOVEL CHEMOPREVENTIVE AGENTS IN EXPERIMENTAL MAMMARY CARCINOGENESIS
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批准号:6160975
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND MOLECULAR BIOLOGY OF TRANSFORMING GROWTH FACTOR-BETA
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批准号:3752614
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND MOLECULAR BIOLOGY OF TRANSFORMING GROWTH FACTOR-BETA
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批准号:3774777
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
NOVEL CHEMOPREVENTIVE AGENTS IN EXPERIMENTAL MAMMARY CARCINOGENESIS
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批准号:2463698
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
STUDY OF MICE IN WHICH THE TGF BETA 1 GENE HAS BEEN DISRUPTED
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批准号:5201576
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND MOLECULAR BIOLOGY OF TRANSFORMING GROWTH FACTOR-BETA
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批准号:3874617
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
EFFECTS OF TRANSFORMING GROWTH FACTOR-BETA ON CARDIAC CELLS
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批准号:3838479
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
STUDY OF MICE IN WHICH THE TGF BETA GENE HAS BEEN DISRUPTED
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批准号:6100869
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
BIOLOGY AND RECEPTOR SIGNALLING OF TRANSFORMING GROWTH FACTOR BETA
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批准号:2463600
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
STUDY OF MICE IN WHICH THE TGF BETA GENE HAS BEEN DISRUPTED
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批准号:6160969
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:A B ROBERTS
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依托单位:
MECHANISM OF ACTION OF TYPE BETA TRANSFORMING GROWTH FACTOR
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批准号:3963417
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
EFFECTS OF TRANSFORMING GROWTH FACTOR-BETA ON CARDIAC CELLS
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批准号:3774900
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A B ROBERTS
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依托单位:
海外基金