EFFECT OF CHLORHEXIDINE ON PERIODONTAL DISEASE IN DIABETES

氯己定对糖尿病牙周病的影响

• 批准号: 5201137
• 负责人: J DRASS
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201137
• 关键词: chlorhexidine; clinical trials; dental disorder chemotherapy; diabetes mellitus; human subject; human therapy evaluation; medical complication; periodontium disorder; therapy compliance

Periodontal disease is the principle oral complication of diabetes mellitus. Chlorhexidine gluconate is an oral antimicrobial mouthrinse that has been uses as a safe and effective agent in preventing and controlling plaque formation in selected populations. Since periodontal diseases are plaque-induced infections, the purpose of this study is to evaluate the effect of chlorhexidine gluconate mouthrinse on periodontal disease in patients with Type II diabetes. This study will also examine the relationships between diabetes control, medication compliance, and the efficacy of chlorhexidine mouthrinse on periodontal disease in this patient population. The study method is a randomized, double-blind , placebo controlled design. A sample of 50 patients with Type II diabetes and early to moderate periodontal disease will be recruited to be randomly assigned to a treatment (chlorhexidine gluconate 0.12% mouthrinse) or control (placebo mouthrinse) group, and stratified by diabetes control and periodontal disease status. Following dental cleaning and examination, subjects will be asked to use study mouthrinse twice a day for 6 months. During the 6 month duration of the study, subjects will be asked to return monthly to the clinic for a nurse interview and compliance, as well as at 3 month intervals for oral measurements, laboratory assessment (glycosylated hemoglobin) and dental prophylaxis. To date, 19 patients have completed the study. Data entry is in process, analysis will follow.

牙周病是糖尿病的主要口腔并发症 糖尿病。葡萄糖酸氯己定是一种口服抗菌漱口水， 已作为一种安全有效的防治剂， 在选定的人群中形成斑块。由于牙周病是 本研究的目的是评价 葡萄糖酸氯己定含漱液治疗牙周病疗效观察 II型糖尿病患者。这项研究还将审查 糖尿病控制、药物依从性和 洗必泰含漱液治疗牙周病疗效观察 患者人群。研究方法为随机、双盲、 安慰剂对照设计。50例II型糖尿病患者样本 和早期至中度牙周病将被随机招募， 分配至治疗组（0.12%葡萄糖酸氯己定漱口液）或 对照组（安慰剂漱口水），并按糖尿病控制和 牙周病的症状在牙齿清洁和检查之后， 要求受试者每天使用研究漱口水两次，持续6个月。 在6个月的研究期间，将要求受试者返回 每月到诊所进行护士面试和遵守，以及在 3个月间隔进行口服测量，实验室评估 （糖化血红蛋白）和牙科预防。迄今为止，19名患者 已完成研究。数据输入正在进行中，随后将进行分析。