Synaptic circuit mechanisms of rhythmic slow oscillatory dynamics in the rodent and human cerebral cortex
啮齿动物和人类大脑皮层节律性慢振荡动力学的突触回路机制
基本信息
- 批准号:MC_UU_12024/4
- 负责人:
- 金额:$ 324.4万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Intramural
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Co-ordinated neuronal activity in the brain is intrinsically linked with behaviour. Malfunction of neuronal coordination results in psychiatric and neurological disorders. Much of the brain activity is rhythmic, as rhythmicity facilitates local and global interactions and enables the representation of temporal sequences. Rhythmicity resets the parameters of neuronal population activity for encoding and delivering information in support of behavioural needs. Importantly, the action of single nerve cells as well as groups of neurons can change systematically relative to the population rhythm and is used by the brain for coding of information.We explore a widespread rhythmicity in the cerebral cortex in the so-called theta frequency range (4-12 cycles per second) in rodents and the homologous brain areas in humans. Theta oscillations are linked to higher frequency oscillations associated with cognitive processes. Such linking of rhythmicity with different frequencies is a basic principle of the brain, as changes in the strength of links indicate behavioural performance, cognitive states such as navigation, decision-making and memory and are impaired by pathology such as dementia. We identify the nerve cells, the links between them, and sites where influencing the memory system with drugs, or changing the activity of selected pathways restores normal rhythmic activity and improves co-ordination by attenuating pathological activity.
大脑中协调的神经元活动与行为有着内在的联系。神经元协调功能障碍会导致精神和神经疾病。大脑的大部分活动是有节奏的,因为有节奏促进了局部和全局的相互作用,并使时间序列的表示成为可能。节律性重置了神经元群体活动的参数,用于编码和传递信息,以支持行为需求。重要的是,单个神经细胞和神经元群的活动可以相对于种群节奏发生系统性的变化,并被大脑用于信息编码。我们探索了啮齿类动物大脑皮层中普遍存在的节律性,其频率范围为所谓的theta频率范围(4-12个周期/秒),以及人类相应的脑区。Theta振荡与认知过程相关的更高频率的振荡有关。这种将不同频率的节律性联系在一起是大脑的基本原理,因为联系强度的变化表明行为表现、认知状态,如导航、决策和记忆,并受到痴呆症等病理因素的损害。我们识别神经细胞,它们之间的联系,以及用药物影响记忆系统的位置,或者改变选定路径的活动,以恢复正常的节律活动,并通过减弱病理活动来改善协调性。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.
- DOI:10.1371/journal.pbio.2006387
- 发表时间:2018-06
- 期刊:
- 影响因子:9.8
- 作者:Harris KD;Hochgerner H;Skene NG;Magno L;Katona L;Bengtsson Gonzales C;Somogyi P;Kessaris N;Linnarsson S;Hjerling-Leffler J
- 通讯作者:Hjerling-Leffler J
Seizing Sequencing Data to Consider Cell and Circuit Complexity
抓住测序数据来考虑细胞和电路的复杂性
- DOI:10.1177/1535759719835658
- 发表时间:2019
- 期刊:
- 影响因子:3.6
- 作者:Christenson Wick Z
- 通讯作者:Christenson Wick Z
Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area.
- DOI:10.1016/j.neuron.2017.10.033
- 发表时间:2017-12-20
- 期刊:
- 影响因子:16.2
- 作者:Joshi A;Salib M;Viney TJ;Dupret D;Somogyi P
- 通讯作者:Somogyi P
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Peter Somogyi其他文献
Chromogranin immunoreactivity in the central nervous system. Immunochemical characterisation, distribution and relationship to catecholamine and enkephalin pathways
中枢神经系统中的嗜铬粒蛋白免疫反应性。
- DOI:
- 发表时间:
1984 - 期刊:
- 影响因子:0
- 作者:
Peter Somogyi;A. Hodgson;R. W. DePotter;Reiner Fischer;M. Schober;Hans Winkler;I. Chubb - 通讯作者:
I. Chubb
Subcellular localization of benzodiazepine/GABAA receptors in the cerebellum of rat, cat, and monkey using monoclonal antibodies
使用单克隆抗体对大鼠、猫和猴子小脑中苯二氮卓/GABAA 受体进行亚细胞定位
- DOI:
- 发表时间:
1989 - 期刊:
- 影响因子:5.3
- 作者:
Peter Somogyi;Hiroshi Takagi;J. Grayson Richards;H. Mohler;Miss Patty Mcchlery;Mr David Roberts;Mr Frank Kennedy - 通讯作者:
Mr Frank Kennedy
Relative densities of synaptic and extrasynaptic GABAA receptors on cerebellar granule cells as determined by a quantitative immunogold method
通过定量免疫金法测定小脑颗粒细胞上突触和突触外 GABAA 受体的相对密度
- DOI:
10.1523/jneurosci.15-04-02948.1995 - 发表时间:
1995 - 期刊:
- 影响因子:4.2
- 作者:
Z. Nusser;J. Roberts;A. Baude;J. G. Richards;Peter Somogyi - 通讯作者:
Peter Somogyi
How can drug discovery for psychiatric disorders be improved?
如何改进精神障碍的药物发现?
- DOI:
10.1038/nrd2217 - 发表时间:
2007-03-01 - 期刊:
- 影响因子:101.800
- 作者:
Yves Agid;György Buzsáki;David M. Diamond;Richard Frackowiak;Jay Giedd;Jean-Antoine Girault;Anthony Grace;Jeremy J. Lambert;Husseini Manji;Helen Mayberg;Maurizio Popoli;Alain Prochiantz;Gal Richter-Levin;Peter Somogyi;Michael Spedding;Per Svenningsson;Daniel Weinberger - 通讯作者:
Daniel Weinberger
Synaptic connections of substance P-immunoreactive nerve terminals in the substantia nigra of the rat
- DOI:
10.1007/bf00218469 - 发表时间:
1982-04-01 - 期刊:
- 影响因子:2.900
- 作者:
Peter Somogyi;J. V. Priestley;A. C. Cuello;A. D. Smith;J. P. Bolam - 通讯作者:
J. P. Bolam
Peter Somogyi的其他文献
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{{ truncateString('Peter Somogyi', 18)}}的其他基金
Synaptic circuit mechanisms of rhythmic oscillatory dynamics in the cerebral cortex
大脑皮层节律振荡动力学的突触回路机制
- 批准号:
MR/R011567/1 - 财政年份:2018
- 资助金额:
$ 324.4万 - 项目类别:
Research Grant
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- 批准号:91132712
- 批准年份:2011
- 资助金额:80.0 万元
- 项目类别:重大研究计划
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揭示可塑性驱动指导信号背后的突触和电路机制
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