巨核细胞特异性基因-猫眼课题宝

巨核细胞特异性基因

批准号：

5201195

负责人：

S ROSENFELD

金额：

$0.0万

依托单位：

CLINICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/5201195

关键词：

blood chemistry blood disorder diagnosis bone marrow disorder genetic markers human tissue immunohematology megakaryocytes method development molecular cloning molecular genetics tissue /cell culture

中文摘要

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英文摘要

We are continuing this project, which began in 1993. We have been working to establish culture and enrichment procedures for human megakaryocytes. Until 8/95, we were working with collections of peripheral blood from normal volunteers. We have now had a protocol approved by the NHLBI IRB for the collection of bone marrow specimens from normal volunteers, which we expect to be richer in megakaryocyte progenitors. Once we have established sufficient enrichment in cultures derived from normal individuals, we will begin collecting samples of bone marrow and peripheral blood from patients with clonal hematologic disorders. We will compare messages from both sources by a variety of techniques.

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