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DOMINANT INHIBITORS OF TAT-INDEPENDENT HIV EXPRESSION AND VIRUS REPLICATION

DOMINANT INHIBITORS OF TAT-INDEPENDENT HIV EXPRESSION AND VIRUS REPLICATION
不依赖 TAT 的 HIV 表达和病毒复制的主要抑制剂
批准号：
5201582
负责人：
D G BLAIR
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5201582
关键词：
DNA binding protein HIV infections HeLa cells chimeric proteins gene expression genetic strain human immunodeficiency virus human tissue oncoproteins tissue /cell culture transcription factor transfection tumor suppressor genes virus genetics virus infection mechanism virus protein virus replication

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英文摘要
A transient transfection assay to test the effect of transiently-expressed, potentially cytotoxic inhibitors on HIV virus infection was developed in HeLa cells. This assay allowed inhibitors known to block expression of HIV-dependent reporter constructs in transient transfection assays to be tested for their effects on virus infection under identical conditions. Initial experiments indicate that a fusion of the DNA-binding domain of NFkappaB p50 and p65 to the inhibitory domain of the ETS family suppressor protein, ERF, is able to reduce the level of HIV p24 expression following transient transfection of HeLa cells and infection with the IIIB strain of HIV.
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