Understanding infectious laryngotracheitis virus recombination

了解传染性喉气管炎病毒重组

• 批准号: DE140100735
• 负责人: Dr Sang-Won Lee
• 金额: $ 11.95万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-11-15 至 2019-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140100735
• 关键词: Understanding; infectious; laryngotracheitis; virus; recombination

This project will study the factors that lead to recombination between strains of infectious laryngotracheitis virus (ILTV) concomitant with increased virulence. In previous studies of ILTV, two new genotypes of virulent field strains were shown to be independent recombinants derived from distinct attenuated ILTV commercial vaccines. These strains became the dominant field viruses responsible for widespread and severe disease outbreaks in Australian poultry flocks. This project will enhance understanding of the conditions that led to these deleterious natural recombination events and enable the industry to avoid the emergence of new virulent field strains in the future.

该项目将研究导致传染性喉气管炎病毒（ILTV）毒株之间重组并伴随毒力增加的因素。在之前的 ILTV 研究中，两种新的强毒力野毒株基因型被证明是源自不同的减毒 ILTV 商业疫苗的独立重组体。这些菌株成为导致澳大利亚家禽群广泛而严重疾病暴发的主要田间病毒。该项目将加深对导致这些有害自然重组事件的条件的了解，并使该行业能够避免未来出现新的剧毒菌株。