ASSEMBLY OF THE ACETYLCHOLINE RECEPTOR

烟碱乙酰胆碱受体（AChR）是一个五聚体 亚基组成为α 2 β γ δ的膜蛋白。 这五个亚基在它们的中心形成离子通道， 闭合由乙酰胆碱的结合控制。 述烟碱 肌肉中的AChR是神经递质大家族中研究得最好的 受体，包括GABA甘氨酸和神经AChR的受体。 谷氨酸受体根据类似的模式形成，但 更远的亲戚。 我们的实验室研究的结构，功能， 和肌肉中烟碱AChR的组装。 我们调查了 肌细胞和异源细胞中受体的性质， 其在受体亚基cDNA转染后表达AChR。 由于家庭成员的相似性， 作为其他受体的模型，这些受体是AChR的靶点。 与治疗精神疾病有关的药物。

The nicotinic acetylcholine receptor (AChR) is a pentameric integral membrane protein with the subunit composition alpha2beta gamma delta. The five subunits form an ion channel at their center whose opening and closing is controlled by the binding of acetylcholine. The nicotinic AChR in muscle is the best-studied of a large family of neurotransmitter receptors that include the receptor for GABA glycine and the neural AChR. Glutamate receptors are formed according to a similar pattern, but are more distantly related. Our laboratory studies the structure, function, and assembly of the nicotinic AChR in muscle. We investigate both the properties of the receptors in muscle cells and in heterologous cells in which the AChR is expressed after transfection of receptor subunit cDNA. Because of the similarity of members of the family, findings that relate to the AChR serve as a model for other receptors, which are targets for drugs that are relevant to the treatment of mental illness.