STRUCTURE AND ASSEMBLY OF THE ACETYLCHOLINE RECEPTOR

烟碱型乙酰胆碱受体(AChR)是一个五元积分 膜蛋白的亚基组成为α2beta-γ-Delta。 五个亚基在其中心形成离子通道，其开口和 关闭是由乙酰胆碱的结合控制的。尼古丁 Achr是肌肉是一个神经递质大家族中研究最多的 包括GABA甘氨酸受体和神经的受体 Achr.谷氨酸受体是根据类似的模式形成的，但 有更远的亲缘关系。我们的实验室研究这种结构， 烟碱型AChR n肌肉的功能和组装。我们在调查 肌细胞和异种肌细胞中受体的特性 转染腺病毒受体后表达AChR的细胞 亚基cDNA.由于家族成员的相似性， 与AChR相关的发现为其他受体提供了一个模型， 哪些是与治疗精神疾病相关的药物的靶点 生病了。

The nicotinic acetylcholine receptor (AChR) is a pentarneric integral membrane protein with the subunit composition alpha2beta-gamma-delta . The five subunits form an ion channel at their center whose opening and closing is controlled by the binding of acetylcholine. The nicotinic AChR is muscle is the best-studied of a large family of neurotransmitter receptors that include the receptor for GABA glycine and the neural AChR. Glutamate receptors are formed according to a similar pattern, but are more distantly related. Our laboratory studies the structure, function, and assembly of the nicotinic AChR n muscle. We investigate both the properties of the receptors in muscle cells and in heterologous cells in which the AChR is expressed after transfection of receptor subunit cDNA. Because of the similarity of members of the family, findings that related to the AChR serve as a model for other receptors, which are targets for drugs that are relevant to the treatment of mental illness.