Trajectory of Brain Structure and Function before and after the Onset of Psychosis: a Longitudinal Multicentre Study

精神病发作前后大脑结构和功能的轨迹：一项纵向多中心研究

• 批准号: MR/J008915/1
• 负责人: Matthew Kempton
• 金额: $ 156.47万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ008915%2F1
• 关键词: Trajectory; Brain; Structure; Function; before

Psychotic disorders such as schizophrenia are disabling and relatively common conditions. They usually begin in early adulthood, and are chronic illnesses. Treatment can partially reduce some of the symptoms, but is not curative. These disorders are preceded by an 'at risk mental state' (ARMS). People in this state have a 30% risk of developing psychosis. However, at present, it is not possible to predict which individual with an ARMS will go on to develop psychosis and which will not. The aim of my study is to test whether measuring the structure and function of the brain with Magnetic Resonance Imaging (MRI) scanning in people with an ARMS can help clinicians to predict who will later become ill. In order to do this, I will put together a large number of scans collected from several different research centres in Europe and Australia. People with an ARMS who take part in the study will be scanned when they first contact support clinics, and then again after 3 months, 12 months and 24 months. I will use the information in the scans to test whether the way the brain changes over time is different in people who will later develop psychosis compared to people who do not. There is evidence to suggest that specific regions of the brain called the hippocampus, insula and lateral ventricles change in volume close to the time-point that a psychotic illness starts. However it is not known exactly when these changes occur and if they happen before or after the beginning of psychosis. From the MRI scans I will be able to discover exactly when these changes occur. One popular theory of schizophrenia proposes that a region of the brain called the hippocampus becomes abnormally active and then causes problems in regulating another region of the brain called the striatum which is important in symptoms of psychosis. I will test this theory by using the MRI scans to measure the activity of the hippocampus compared to activity in the striatum.

精神疾病，如精神分裂症是致残和相对常见的条件。它们通常开始于成年早期，是慢性疾病。治疗可以部分减轻一些症状，但不能治愈。这些疾病之前是一个“危险的精神状态”（ARMS）。这种状态的人有30%的风险患上精神病。然而，目前还不可能预测哪个ARMS患者会发展成精神病，哪个不会。我研究的目的是测试是否测量与磁共振成像（MRI）扫描的人与ARMS的大脑的结构和功能可以帮助临床医生预测谁以后会生病。为了做到这一点，我将把从欧洲和澳大利亚的几个不同研究中心收集的大量扫描数据放在一起。参加研究的ARMS患者将在首次联系支持诊所时进行扫描，然后在3个月，12个月和24个月后再次进行扫描。我将使用扫描中的信息来测试大脑随时间变化的方式是否在以后发展为精神病的人与没有发展为精神病的人之间存在差异。有证据表明，大脑中被称为海马体、侧脑室和侧脑室的特定区域在接近精神病开始的时间点时体积会发生变化。然而，这些变化发生的确切时间以及它们是否发生在精神病开始之前或之后并不清楚。通过MRI扫描，我将能够准确地发现这些变化发生的时间。一种流行的精神分裂症理论认为，大脑中一个叫做海马体的区域变得异常活跃，然后导致调节大脑中另一个叫做纹状体的区域出现问题，纹状体在精神病症状中很重要。我将通过使用MRI扫描来测量海马体的活动与纹状体的活动进行比较，以验证这一理论。

项目成果

Influence of cannabis use on incidence of psychosis in people at clinical high risk.

• DOI: 10.1111/pcn.13555
• 发表时间: 2023-09
• 期刊: Psychiatry and clinical neurosciences
• 影响因子: 11.9
• 作者: Chester LA;Valmaggia LR;Kempton MJ;Chesney E;Oliver D;Hedges EP;Klatsa E;Stahl D;van der Gaag M;de Haan L;Nelson B;McGorry P;Amminger GP;Riecher-Rössler A;Studerus E;Bressan R;Barrantes-Vidal N;Krebs MO;Glenthøj B;Nordentoft M;Ruhrmann S;Sachs G;McGuire P;EU-GEI High Risk Study Group
• 通讯作者: EU-GEI High Risk Study Group

Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder.

• DOI: 10.1176/appi.ajp.2018.17111199
• 发表时间: 2018-10-01
• 期刊: The American journal of psychiatry
• 作者: Bromis K;Calem M;Reinders AATS;Williams SCR;Kempton MJ
• 通讯作者: Kempton MJ

Verbal learning and hippocampal dysfunction in schizophrenia: A meta-analysis.

• DOI: 10.1016/j.neubiorev.2017.12.001
• 发表时间: 2018-03
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Antoniades M;Schoeler T;Radua J;Valli I;Allen P;Kempton MJ;McGuire P
• 通讯作者: McGuire P

A voxel-based morphometry comparison of the 3.0T ADNI-1 and ADNI-2 volumetric MRI protocols.

3.0T ADNI-1 和 ADNI-2 体积 MRI 协议基于体素的形态测量比较。

• DOI: 10.1002/gps.4179
• 发表时间: 2015-05
• 期刊: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 4
• 作者: Brunton, Simon;Gunasinghe, Cerisse;Jones, Nigel;Kempton, Matthew J.;Westman, Eric;Simmons, Andrew
• 通讯作者: Simmons, Andrew

Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples.

• DOI: 10.1016/j.nicl.2017.02.016
• 发表时间: 2017
• 期刊: NeuroImage. Clinical
• 作者: Calem M;Bromis K;McGuire P;Morgan C;Kempton MJ
• 通讯作者: Kempton MJ