Determining the impact of cytotoxic therapies on the bone marrow microenvironment

确定细胞毒疗法对骨髓微环境的影响

• 批准号: nhmrc : 1006485
• 负责人: A/Pr Louise Purton
• 金额: $ 41.44万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-impact-cytotoxic-marrow-microenvironment/109184
• 关键词: Determining; impact; cytotoxic; therapies; bone

Treatments for cancers result in markedly impaired blood cell production. Non-blood cell types within the bone marrow (BM) microenvironment are important to the regulation of blood cell production. We have evidence these cancer treatments also damage the BM microenvironment. We aim to fully explore how cancer treatments impact on the BM microenvironment. We can then determine how to improve recovery of the BM microenvironment in order to rapidly restore blood cell production after treatment.

癌症的治疗导致血细胞生成明显受损。骨髓（BM）微环境中的非血细胞类型对血细胞产生的调节很重要。我们有证据表明这些癌症治疗也会损害BM微环境。我们的目标是充分探索癌症治疗如何影响BM微环境。然后，我们可以确定如何改善BM微环境的恢复，以便在治疗后快速恢复血细胞生成。