TNFα 对骨和造血作用影响的机制-猫眼课题宝

TNFα 对骨和造血作用影响的机制

批准号：

nhmrc : 502612

负责人：

A/Pr Louise Purton

金额：

$39.3万

依托单位：

St. Vincent's Institute of Medical Research

依托单位国家：

澳大利亚

项目类别：

NHMRC Project Grants

财政年份：

2008

资助国家：

澳大利亚

项目状态：

已结题

起止时间：

2008-01-01 至 2010-12-31

来源：

https://researchdata.edu.au/mechanisms-underlying-effects-bone-haemopoiesis/101043

关键词：

Mechanisms underlying effects TNFalpha bone

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英文摘要

Recent studies have identified that bone plays an important role in blood cell production. We have discovered that elevated levels of TNF alpha (which increases with ageing and can negatively impact on health) contributes to a blood cell disorder that can progress to leukaemia. There are also reduced numbers of blood stem cells and bone in this mouse model. In these studies we will determine how TNFalpha contributes to blood and bone defects, which may lead to better treatment of such diseases.

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