Determining the mechanistic basis of the patterns of inverse drug susceptibility induced by two key drug resistance proteins of the malaria parasite.

确定疟疾寄生虫的两种关键耐药蛋白诱导的反向药物敏感性模式的机制基础。

• 批准号: nhmrc : GNT1127338
• 负责人: Dr Adele Lehane
• 金额: $ 56.73万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-mechanistic-basis-malaria-parasite/1347620
• 关键词: Determining; mechanistic; basis; patterns; inverse

The inexhaustible capacity of many pathogens and cancers to develop resistance to new drugs is a serious threat to world health. Yet in acquiring resistance to one drug, many pathogens and cancer cells become hypersensitive to one or more other drugs. We seek to elucidate several of the molecular mechanisms underpinning this phenomenon in the malaria parasite. Insights gained from this work will contribute to the formulation of new therapeutic strategies that overcome or retard drug resistance.

许多病原体和癌症对新药产生抗药性的无穷能力是对世界健康的严重威胁。然而，在获得对一种药物的耐药性时，许多病原体和癌细胞对一种或多种其他药物变得高度敏感。我们试图阐明几个支持这种现象的疟疾寄生虫的分子机制。从这项工作中获得的见解将有助于制定新的治疗策略，克服或延缓耐药性。