Ion regulation in Apicomplexan parasites

顶复门寄生虫中的离子调节

• 批准号: DE160101035
• 负责人: Dr Adele Lehane
• 金额: $ 27.67万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE160101035
• 关键词: Ion; regulation; Apicomplexan; parasites

This project aims to determine how Apicomplexan parasites regulate their sodium and chloride levels to support the development of new parasite control measures. Apicomplexan parasites cause devastating animal and human diseases. Little is known about the physiology of these parasites, and options for controlling them are few. Apicomplexan parasites must precisely control their internal ion compositions in order to survive, but how they do so is not understood. Recent work has identified a unique Apicomplexan sodium transporter and revealed a number of chloride transporter candidates. Using a combination of molecular biology and physiological techniques, this project aims to characterise the Apicomplexan sodium transporter in detail and elucidate the molecular mechanisms of chloride transport.

该项目旨在确定顶复门寄生虫如何调节其钠和氯化物水平，以支持新的寄生虫控制措施的发展。顶复门寄生虫引起毁灭性的动物和人类疾病。人们对这些寄生虫的生理学知之甚少，控制它们的选择也很少。顶复门寄生虫必须精确地控制它们内部的离子组成才能生存，但它们是如何做到这一点的还不清楚。最近的工作已经确定了一个独特的Apicomplexan钠转运蛋白，并揭示了一些氯离子转运蛋白的候选者。本项目旨在结合分子生物学和生理学技术，对顶复门纲钠转运蛋白进行详细的研究，阐明氯离子转运的分子机制。