MODULATION OF NATURAL DEFENSE IN ORAL DISEASE DRI

口腔疾病 DRI 中自然防御的调节

• 批准号: 2015043
• 负责人: MICHAEL J LEVINE
• 金额: $ 80.23万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2015043
• 关键词: Bacteroides gingivalis; host organism interaction; oral bacteria; periodontium disorder; saliva; xerostomias

The primary goal of the RCOB at State University of New York at Buffalo is to expand the scientific base that underlies the nation's capability to prevent and control oral diseases and disorders and to improve oral health. Our scientific expertise and facilities were greatly expanded during the previous granting period through a combination of RCOB and University resources. This enables RCOB scientists to address scientific problems in an integrated fashion using protein chemistry, molecular biology, biophysics, immunology, microbiology and cell biology. The secondary goal of the RCOB is to maintain a center of excellence that will attract investigators of high quality to dental research, continue our long- standing tradition of research training at all levels of career development, and serve as a focal point to encourage productive research- related collaborations with other institutions. The Center uses the combined efforts of a team of dentist-scientists, microbiologists, biochemists, biophysicists, molecular biologists and cell biologists from both the School of Dental Medicine and the School of Medicine and Biomedical Sciences at the University at Buffalo. Additionally, scientists from Roswell Park Cancer Institute and the University of Minnesota have joined the Center to augment research efforts. Projects 1, 2 and 3 propose to enhance the protective qualities of saliva by the design and development of salivary substitutes to combat plaque mediated disease in subjects with normal salivary flow as well as those with xerostomia. A multidisciplinary approach involving protein chemistry, molecular biology, biophysics and bioengineering will design and synthesize salivary substances with enhanced functions relating to bacterial clearance/adherence mechanisms and lubrication. Projects 4, 5 and 8 are designed to characterize virulence factors of Porphyromonas gingivalis that might be determinants of disease and to study the immunochemical, biochemical and molecular biological mechanisms by which these factors are expressed and subsequently modulated. Studies will focus on the role of fimbriae in adhesion and outer membrane proteins in bacterial coaggregation and iron regulation.

位于布法罗的纽约州立大学的RCOB的主要目标是 扩大作为国家能力基础的科学基础， 预防和控制口腔疾病和紊乱，改善口腔健康。 我们的科学专业知识和设施在1998年期间得到了极大的扩展。 通过RCOB和大学的组合上一个授予期 资源 这使RCOB科学家能够解决科学问题， 一个综合的方式使用蛋白质化学，分子生物学， 生物物理学、免疫学、微生物学和细胞生物学。 次要目标 的RCOB是保持一个卓越的中心，将吸引 高质量的牙科研究人员，继续我们的长期- 在职业生涯的各个层次进行研究培训的长期传统 发展，并作为一个重点，鼓励生产性研究- 与其他机构的相关合作。 该中心使用 一个由牙医科学家，微生物学家， 生物化学家、生物化学家、分子生物学家和细胞生物学家， 牙科医学院和医学院， 布法罗大学的生物医学科学。 此外，科学家 来自罗斯威尔公园癌症研究所和明尼苏达大学的研究人员 加入中心以加强研究工作。 项目1、2和3建议提高唾液的保护质量 通过设计和开发唾液替代品来对抗牙菌斑 在具有正常唾液流的受试者以及那些 口腔干燥症 涉及蛋白质化学的多学科方法， 分子生物学、生物物理学和生物工程学将设计和合成 具有增强的与细菌相关的功能的唾液物质 间隙/粘附机制和润滑。 项目4、5和8旨在表征 牙龈卟啉单胞菌可能是疾病的决定因素， 免疫化学、生物化学和分子生物学机制， 这些因子被表达并随后被调节。 研究将 重点关注菌毛在粘附和外膜蛋白中的作用， 细菌共聚集和铁调节。