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MODULATION OF NATURAL DEFENSE IN ORAL DISEASE DRI

口腔疾病 DRI 中自然防御的调节

基本信息

批准号：
2697635
负责人：
MICHAEL J LEVINE
金额：
$ 82.64万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-09-01 至 1999-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2697635
关键词：
Bacteroides gingivalis host organism interaction oral bacteria periodontium disorder saliva xerostomias

项目摘要

The primary goal of the RCOB at State University of New York at Buffalo is to expand the scientific base that underlies the nation's capability to prevent and control oral diseases and disorders and to improve oral health. Our scientific expertise and facilities were greatly expanded during the previous granting period through a combination of RCOB and University resources. This enables RCOB scientists to address scientific problems in an integrated fashion using protein chemistry, molecular biology, biophysics, immunology, microbiology and cell biology. The secondary goal of the RCOB is to maintain a center of excellence that will attract investigators of high quality to dental research, continue our long- standing tradition of research training at all levels of career development, and serve as a focal point to encourage productive research- related collaborations with other institutions. The Center uses the combined efforts of a team of dentist-scientists, microbiologists, biochemists, biophysicists, molecular biologists and cell biologists from both the School of Dental Medicine and the School of Medicine and Biomedical Sciences at the University at Buffalo. Additionally, scientists from Roswell Park Cancer Institute and the University of Minnesota have joined the Center to augment research efforts. Projects 1, 2 and 3 propose to enhance the protective qualities of saliva by the design and development of salivary substitutes to combat plaque mediated disease in subjects with normal salivary flow as well as those with xerostomia. A multidisciplinary approach involving protein chemistry, molecular biology, biophysics and bioengineering will design and synthesize salivary substances with enhanced functions relating to bacterial clearance/adherence mechanisms and lubrication. Projects 4, 5 and 8 are designed to characterize virulence factors of Porphyromonas gingivalis that might be determinants of disease and to study the immunochemical, biochemical and molecular biological mechanisms by which these factors are expressed and subsequently modulated. Studies will focus on the role of fimbriae in adhesion and outer membrane proteins in bacterial coaggregation and iron regulation.

纽约州立大学布法罗分校 RCOB 的主要目标是扩大支撑国家能力的科学基础预防和控制口腔疾病和紊乱，改善口腔健康。在此期间，我们的科学专业知识和设施得到了极大的扩展之前通过 RCOB 和大学联合授予的资助期资源。这使得 RCOB 科学家能够解决以下领域的科学问题：一种利用蛋白质化学、分子生物学的综合时尚，生物物理学、免疫学、微生物学和细胞生物学。次要目标 RCOB 的目标是维持一个卓越中心，吸引高质量的牙科研究研究人员，继续我们的长期在职业生涯的各个层面进行研究培训的悠久传统发展，并作为鼓励富有成效的研究的焦点与其他机构的相关合作。该中心使用牙医科学家、微生物学家团队的共同努力，来自生物化学家、生物物理学家、分子生物学家和细胞生物学家牙科医学院和医学院布法罗大学生物医学科学。此外，科学家来自罗斯威尔帕克癌症研究所和明尼苏达大学的加入该中心以加强研究工作。项目1、2和3建议增强唾液的保护质量通过设计和开发唾液替代品来对抗牙菌斑唾液流量正常的受试者以及那些患有口干症。涉及蛋白质化学的多学科方法，分子生物学、生物物理学和生物工程将设计和合成与细菌有关的具有增强功能的唾液物质间隙/粘附机制和润滑。项目 4、5 和 8 旨在表征牙龈卟啉单胞菌可能是疾病的决定因素并进行研究免疫化学、生化和分子生物学机制这些因素被表达并随后被调节。研究将重点关注菌毛在粘附和外膜蛋白中的作用细菌共聚集和铁调节。