PILOT STUDY--INFLUENCES ON INJURY OUTCOME AFTER MASSIVE TRANSFUSION

这项前瞻性的初步研究旨在探讨 与损伤相关的生理、免疫和心理变量之间 和具体的损伤相关结果。 研究问题导向 本研究的主要内容是：1. 什么是伤害类型的影响，伤害 严重程度和免疫状态对创伤性损伤后生存的影响 需要大量输血吗 和2. 类型的影响是什么 损伤，损伤严重程度，免疫状态和心理困扰， 住院时间、并发症数量和功能恢复情况？ 一 25人的样本，持续创伤性损伤，需要更大的 超过10个单位的红细胞压积后的前24小时内， 将被纳入研究。 将对受试者进行随访 纵向3个月。 数据收集：受伤后， 复苏开始前（T1）、2天（T2）、7天（T3）、1个月 T4）和3个月（T5）。 收集的数据包括静脉血样， 免疫表型（T1、T2、T3、T5）和肝炎血清学（T1、T4、T5）; 生存率、并发症、住院时间（T5时的病历审核）; 计算机创伤登记处（T5）的损伤和损伤严重程度;以及 心理困扰的结构化访谈（T3，T4，T5）， 功能恢复（T5）。 将使用描述性方法分析数据 统计和双变量分析。 这项试点研究的结果将 提供初步数据，以确定大规模的可行性 创伤对机体生理、免疫和心理影响的研究 危及生命的损伤后选定结局的变量 需要大量输血 随后的研究将侧重于 制定和测试跨学科干预措施， 生存率，最大限度地减少继发性并发症，控制住院时间， 成本，并加强功能恢复后，危及生命 受伤

This prospective pilot study is designed to explore the relationship between injury-related physical, immunologic, and psychologic variables and specific injury-related outcomes. The research questions guiding this study are: 1. What is the influence of type of injury, injury severity, and immune status on survival following traumatic injury requiring massive transfusion? and 2. What is the influence of type of injury, injury severity, immune status, and psychological distress on length of stay, number of complications, and functional recovery? A sample of 25 individuals, sustaining traumatic injury requiring greater than 10 units of packed red blood cells within the first 24 hours after injury will be enrolled in the study. Subjects will be followed longitudinally for 3 months. Data will be collected: after injury but before resuscitation commences (T1), 2 days (T2), 7 days (T3), 1 month T4), and 3 months (T5). Data collected includes venous blood samples fo immune phenotypes (T1, T2, T3, T5) and hepatitis serology (T1, T4, T5); survival, complications, length of stay (chart audit at T5); type of injury and injury severity from computerized trauma registry (T5); and structured interviews for psychological distress (T3, T4, T5) and functional recovery (T5). Data will be analyzed using descriptive statistics and bivariate analysis. Results from this pilot study will provide preliminary data to determine the feasibility of a large scale study of the influence of injury-related physical, immune and psychologi variables on selected outcomes following life-threatening injury requiring massive transfusion. Subsequent studies will focus on the development and testing of interdisciplinary interventions to improve survival, minimize secondary complications, control length of stay and costs, and enhance functional recovery following life-threatening injuries.