EPIDEMIOLOGY OF IDDM IN BLACKS

本研究的目的是确定是否缺乏天冬氨酸 在HLA-DO β链的位置57处存在精氨酸， 52的HLA-DO α链是一个强大的遗传标记，在非洲 与白种人一样，美国人也有胰岛素依赖型糖尿病。 似乎有一个5倍的 居住在不同地区的非裔美国人中胰岛素依赖型糖尿病风险的差异 所看到的变化可能是由于存在或不存在 这些遗传标记可能与高加索人的程度有关， 在美国各地的非洲裔美国人的混合物，这是很重要的， 建立一个基于人群的糖尿病登记处，以表征遗传 胰岛素依赖型糖尿病的易感性，因为它与HLA等位基因有关。 华盛顿，华盛顿特区 提供了一个独特的机会，检查发病率数据和遗传风险 与非裔美国人的胰岛素依赖型糖尿病相关的因素， 他们中的一部分人居住在该地区。 的理解 非裔美国人的胰岛素依赖型糖尿病的遗传风险，预防策略可以是 更有效地执行。 该项目的具体目标是：（1）确定 1990年至1999年年龄以下的非裔美国儿童中的胰岛素依赖型糖尿病 从华盛顿，华盛顿特区来的15年里，(2)确定在何种程度上， HLA-II类基因的分子多态性与胰岛素依赖型糖尿病相关 来自华盛顿，华盛顿特区的非裔美国人的易感性，(3)评价 与HLA II类相关的基因型特异性IDDM发病率 易感基因，（4）比较基因型分布和 非裔美国人基因型特异性胰岛素依赖型糖尿病发病率 华盛顿，华盛顿特区，已在美国注册

The objective of this study is to determine if the absence of apartic acid at position 57 of the HLA-DObeta chain and presence of arginine at position 52 of the HLA-DOalpha chain is as strong of a genetic marker in African Americans for IDDM as it is in Caucasians. There appears to be a 5-fold difference in IDDM risk among African Americans residing in various areas of the U.S. The variations seen may be due to the presence or absence of these genetic markers which may be related to the degree of Caucasian admixture in African Americans across the U.S. It is important to establish a population-based diabetes registry to characterized the genetic susceptibility of IDDM as it relates to HLA alleles. Washington, D.C. provides an unique opportunity to examine incidence data and genetic risk factors associated with IDDM in African Americans because of the large percentage of them residing in the area. With an understanding of the genetic risks of IDDM in African Americans, preventive strategies can be more effectively implemented. The specific aims of this project are to: (1) determine the incidence of IDDM from 1990 to 1999 among African American children les than the age of 15 years from Washington, D.C., (2) determine the degree to which the molecular polymorphisms of HLA class II genes are associated with IDDM susceptibility among African Americans from Washington, D.C., (3) evaluate the genotype-specific IDDM incidence rates associated with HLA class II susceptibility genes, and (4) compare the genotype distributions and the genotype specific IDDM incidence rates among African Americans from Washington, D.C. with established registries in the U.S.