EPIDEMIOLOGY OF IDDM IN BLACKS

这项研究的目的是确定天冬氨酸的缺乏 在HLA-DObeta链的57位和精氨酸的存在 在非洲，人类白细胞抗原-DOAlpha链的52是一种很强的遗传标记 美国人对IDDM的态度就像在高加索人一样。看起来有5倍的 居住在不同地区的非裔美国人患IDDM风险的差异 出现的变化可能是由于存在或不存在 这些遗传标记可能与高加索人的程度有关 在美国各地的非裔美国人中混杂。重要的是 建立以人群为基础的糖尿病登记，以表征基因 IDDM的易感性与HLA等位基因有关。华盛顿特区。 提供独特的机会来检查发病率数据和遗传风险 非裔美国人中与IDDM相关的因素，因为 他们中有百分比居住在该地区。在了解了 在非裔美国人中，IDDM的遗传风险，预防策略可以 更加有效地实施。 本项目的具体目标是：(1)确定发病率 1990至1999年间非洲裔美国儿童中年龄小于 离开华盛顿特区15年，(2)确定 人类白细胞抗原II类基因分子多态性与IDDM的关系 华盛顿非裔美国人的易感性，(3)评估 人类白细胞抗原II类与特定基因型的IDDM发病率相关 易感基因，以及(4)比较基因分布和易感基因。 来自中国的非洲裔美国人中特定基因型的IDDM发病率 华盛顿特区，在美国已有注册

The objective of this study is to determine if the absence of apartic acid at position 57 of the HLA-DObeta chain and presence of arginine at position 52 of the HLA-DOalpha chain is as strong of a genetic marker in African Americans for IDDM as it is in Caucasians. There appears to be a 5-fold difference in IDDM risk among African Americans residing in various areas of the U.S. The variations seen may be due to the presence or absence of these genetic markers which may be related to the degree of Caucasian admixture in African Americans across the U.S. It is important to establish a population-based diabetes registry to characterized the genetic susceptibility of IDDM as it relates to HLA alleles. Washington, D.C. provides an unique opportunity to examine incidence data and genetic risk factors associated with IDDM in African Americans because of the large percentage of them residing in the area. With an understanding of the genetic risks of IDDM in African Americans, preventive strategies can be more effectively implemented. The specific aims of this project are to: (1) determine the incidence of IDDM from 1990 to 1999 among African American children les than the age of 15 years from Washington, D.C., (2) determine the degree to which the molecular polymorphisms of HLA class II genes are associated with IDDM susceptibility among African Americans from Washington, D.C., (3) evaluate the genotype-specific IDDM incidence rates associated with HLA class II susceptibility genes, and (4) compare the genotype distributions and the genotype specific IDDM incidence rates among African Americans from Washington, D.C. with established registries in the U.S.