FIBER TYPE COMPOSITION OF FACIAL MUSCLES

面部肌肉的纤维类型组成

• 批准号: 5212004
• 负责人: LAWRENCE EDWARD WINESKI
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5212004
• 关键词: facial muscles; fiber cell; guinea pigs; hamsters; histology; immunocytochemistry; laboratory rat; morphology; myofibrils; neuroanatomy; neuromuscular function

The scientific objective of this project is to utilize the vibrissal motor system (VMS) of rodents as a model for experimental studies of the facial muscles in the orofacial region. This will be accomplished by employing three representative species (golden hamster, rat, guinea pig) to test the general hypothesis that different types of orofacial behavior (e.g., different categories of vibrissal movement) reflect different patterns of neural organization of the facial muscles. One specific aim is designed to test the general hypothesis regarding likely levels of organization. The general hypothesis is that homologous facial muscles with dissimilar functions have dissimilar patterns of neural organization. To test this, Specific Aim (1) is to determine the fiber type composition of the vibrissal facial muscles in each species via both enzyme histochemical and immunocytochemical methods, and to compare the three species. A VMS model of the facial musculature would provide new information on the functional properties of facial muscles. This could be valuable clinically in forming the basis of understanding for (1) applied studies of steroid therapy for treatment of facial muscle injury, and (2) facial muscle response to individual muscle response to individual muscle and/or whole flap transposition for orofacial paralysis and/or reconstruction. The second objective of this project is to educate students in the life sciences, specifically, in research in the field of neuromuscular biology. To accomplish this, one undergraduate student will be trained in the context of the above study.

这个项目的科学目标是利用触须 运动系统（VMS）的啮齿动物作为模型的实验研究， 口面部区域的面部肌肉。 这将通过 采用三种代表性种属（金黄仓鼠、大鼠、豚鼠） 为了验证不同类型的口面神经 行为（例如，不同种类的触须运动）反映 面部肌肉神经组织的不同模式。 一 一个特定的目的是为了测试关于可能的一般假设， 组织层次。 一般的假设是， 不同功能的面部肌肉有不同的模式， 神经组织 为了验证这一点，具体目标（1）是确定 各物种面触须肌的纤维型组成 通过酶组织化学和免疫细胞化学方法， 对比一下这三个物种。 面部肌肉组织的VMS模型将 提供了面部肌肉功能特性的新信息。 这可能是有价值的临床形成的基础，了解 用于（1）类固醇治疗面部疾病的应用研究 肌肉损伤，以及（2）面部肌肉对单个肌肉的反应 对单个肌肉和/或整个皮瓣移位的反应， 口面神经麻痹和/或重建。 第二个目标是 项目是教育学生在生命科学，具体来说，在 神经肌肉生物学领域的研究。 为了做到这一点，一 本科生将在上述研究的背景下接受培训。