Exploring frailty, mental health and related outcomes: a multi-cultural population-based approach to ageing.

探索虚弱、心理健康和相关结果：基于多元文化人口的老龄化方法。

• 批准号: MR/K021907/1
• 负责人: Matthew Prina
• 金额: $ 30.03万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK021907%2F1
• 关键词: Exploring; frailty; mental; health; related

We are facing an unparalleled change in demographics, where people are increasingly living longer. This phenomenon is occurring across the whole globe, but at a different pace. Rich countries have experienced a steadier increase in the number of older adults, whereas low and middle-income countries are facing a much more rapid transition. Frailty is closely linked to older age. Although the word 'frail' has become part of our day-to-day vocabulary, geriatricians and the wider medical community have seen far less agreement as to what constitutes a frailty syndrome. The past two decades have seen remarkable advances in understanding this condition, with a number of definitions been put forward. Having a solid and appropriate definition of frailty is extremely important, as without such definition most clinicians would fall back on instinct and experience to identify frail patients. Although there has been considerable progress in the understanding of this condition, most of the work has been carried out in high-income countries and has been mainly driven by clinical insights. It is therefore not known whether the criteria that are currently used in those settings could be used in low and middle-income countries. In this project I aim to investigate whether the current definitions of frailty could be applied to diverse settings, including developing countries, and whether these definitions are good at predicting a range of outcomes. These outcomes include death, illness, disability, cognitive decline and usage of health care. A significant part of the research will focus on the contribution of common mental disorders, such as anxiety and depression, to frailty. The study of anxiety and depression in later life has been relatively neglected, because of an emphasis on acute psychiatric disorders in younger life and the dementias in older age. However these conditions are extremely common in older age and have been associated with higher level of disability, hospitalisation, and lower quality of life. More treatment and research in those conditions should be made a national priority. The research will be novel using a comprehensive and integrative approach in respect to cognitive, physical and psychological age-related changes, and using cutting-edge statistical analytical procedures. This project will also be using data from three large population-based studies carried out in diverse settings. One was carried out across a number of low and middle-income countries in Latin America and Asia. The other two were conducted in the Netherlands and Scotland. The findings from this research will help in developing tools that may help clinicians in predicting the course of illness and its treatment, but also policy-makers and commissioners in planning health care facilities and prioritise resources.

我们正面临着前所未有的人口结构变化，人们的寿命越来越长。这种现象正在全球范围内发生，但速度不同。富裕国家的老年人数量稳步增加，而低收入和中等收入国家正面临着更快的转型。虚弱与年老密切相关。虽然‘虚弱’这个词已经成为我们日常词汇的一部分，但对于什么是虚弱综合症，老年病医生和更广泛的医学界还没有达成一致意见。在过去的二十年里，对这种情况的理解取得了显著的进步，提出了许多定义。对虚弱有一个可靠和适当的定义是极其重要的，因为如果没有这样的定义，大多数临床医生将依靠本能和经验来识别虚弱的患者。尽管对这种情况的理解已经取得了相当大的进展，但大多数工作都是在高收入国家进行的，主要是由临床见解推动的。因此，目前在这些背景下使用的标准是否可用于低收入和中等收入国家尚不得而知。在这个项目中，我的目标是调查目前对脆弱性的定义是否可以适用于不同的环境，包括发展中国家，以及这些定义是否擅长预测一系列结果。这些结果包括死亡、疾病、残疾、认知能力下降和卫生保健的使用。这项研究的很大一部分将集中在常见的精神障碍，如焦虑和抑郁，对脆弱的贡献。对晚年焦虑和抑郁的研究相对被忽视，因为重点是年轻时的急性精神障碍和老年时的痴呆症。然而，这些情况在老年人中非常常见，并与更高水平的残疾、住院和较低的生活质量有关。在这些情况下，更多的治疗和研究应该成为国家的优先事项。这项研究将是新颖的，使用与认知、身体和心理年龄相关的变化的全面和综合的方法，并使用尖端的统计分析程序。该项目还将使用在不同环境中进行的三项大型人口研究的数据。一项是在拉丁美洲和亚洲的一些低收入和中等收入国家进行的。另外两项是在荷兰和苏格兰进行的。这项研究的发现将有助于开发工具，这些工具可能有助于临床医生预测病程及其治疗，也有助于政策制定者和专员规划卫生保健设施和优先安排资源。

项目成果

Commentary: Depression and Incidence of Frailty in Older People From Six Latin American Countries by Prina et al.

评论：Prina 等人的《来自六个拉丁美洲国家的老年人的抑郁症和虚弱发生率》。

• DOI: 10.1016/j.jagp.2019.05.020
• 发表时间: 2019
• 期刊: official journal of the American Association for Geriatric Psychiatry
• 作者: Brown PJ

IS DEMENTIA PREVALENCE RISING OR DECLINING?

痴呆症患病率是上升还是下降？

• 发表时间: 2016
• 期刊: NEUROBIOLOGY OF AGING
• 影响因子: 4.2
• 作者: Albanese Emiliano

Late-life depression symptom dimensions and cognitive functioning in the Longitudinal Aging Study Amsterdam (LASA).

• DOI: 10.1016/j.jad.2016.05.027
• 发表时间: 2016-09-01
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Brailean A;Comijs HC;Aartsen MJ;Prince M;Prina AM;Beekman A;Huisman M
• 通讯作者: Huisman M

Cohort Differences in Cognitive Aging in the Longitudinal Aging Study Amsterdam.

• DOI: 10.1093/geronb/gbw129
• 发表时间: 2018-09-20
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Brailean A;Huisman M;Prince M;Prina AM;Deeg DJH;Comijs H
• 通讯作者: Comijs H

Longitudinal associations between late-life depression dimensions and cognitive functioning: a cross-domain latent growth curve analysis.

• DOI: 10.1017/s003329171600297x
• 发表时间: 2017-03
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Brailean A;Aartsen MJ;Muniz-Terrera G;Prince M;Prina AM;Comijs HC;Huisman M;Beekman A
• 通讯作者: Beekman A