MICA: Training and Novel Probes Programme in PET Neurochemistry - PET Call

MICA：PET 神经化学培训和新型探针计划 - PET Call

• 批准号: MR/K02308X/1
• 负责人: Franklin Aigbirhio
• 金额: $ 129.57万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK02308X%2F1
• 关键词: MICA; Training; Novel; Probes; Programme

Some radioactive molecules emit gamma radiation that can be detected outside the body and so when injected into humans and animals, in safe low levels, can be used to generate images, using sophisticated scanners, of the brain for biomedical research and clinical diagnosis. However, the molecules have to be designed to target the sites of the brain to be investigated, which is done by attaching a biological compound to the radioactive molecule to create products called radiopharmaceuticals. Due to the severe lack of scientists in the UK who have the specialised skills to design and prepare these radiopharmaceuticals we plan to recruit and train a scientist to join our multidisplicinary team. To achieve this we have created a bespoke training programme which will involve learning from researchers in academia and industry, who are either developing and/or using this imaging technology. As part of this training the scientist will help design new radiopharmaceuticals that would then be used in our on-going research programmes to understand the biological mechanisms of some major diseases and disorders of the brain, and thereby identify some possible treatments. For this specific programme we would be undertaking research projects on traumatic brain injury, depression, schizophrenia, obsessive compulsive disorder and drug addiction.

一些放射性分子会发出伽马辐射，可以在体外检测到，因此当以安全的低水平注射到人类和动物体内时，可以使用先进的扫描仪生成大脑图像，用于生物医学研究和临床诊断。然而，这些分子必须被设计成靶向大脑的部位进行研究，这是通过将生物化合物附着在放射性分子上来制造称为放射性药物的产品来完成的。由于英国严重缺乏具有设计和制备这些放射性药物专业技能的科学家，我们计划招募和培训一名科学家加入我们的多学科团队。为了实现这一目标，我们创建了一个定制的培训计划，其中包括向正在开发和/或使用这种成像技术的学术界和工业界的研究人员学习。作为这项培训的一部分，科学家将帮助设计新的放射性药物，然后用于我们正在进行的研究计划，以了解一些主要疾病和大脑紊乱的生物机制，从而确定一些可能的治疗方法。对于这一具体方案，我们将开展关于创伤性脑损伤、抑郁症、精神分裂症、强迫症和吸毒成瘾的研究项目。

项目成果

Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses

记忆和相关其他疾病炎症的神经影像学 (NIMROD) 研究方案：一项关于脑部炎症在痴呆、抑郁和其他神经系统疾病中的作用的深度表型队列研究

• DOI: 10.17863/cam.6890
• 发表时间: 2017
• 作者: Bevan Jones R

Development and Application of Imaging Probes for Molecular Imaging by Positron Emission Tomography

正电子发射断层扫描分子成像成像探针的研制与应用

• DOI: 10.33774/coe-2022-g3hwc
• 发表时间: 2022
• 作者: Aigbirhio F

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

[18F]AV-1451 PET 在 MAPT 突变导致的行为变异型额颞叶痴呆中的应用

• DOI: 10.17863/cam.6334
• 发表时间: 2016
• 作者: Bevan Jones W