Acellular Approaches for Therapeutic Delivery: UK Regenerative Medicine Platform Hub Application

非细胞治疗方法：英国再生医学平台中心应用

• 批准号: MR/K026682/1
• 负责人: Kevin Shakesheff
• 金额: $ 502.61万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK026682%2F1
• 关键词: Acellular; Approaches; Therapeutic; Delivery; UK

Regenerative medicine will transform human health over the next 30 years. We have the ability to create new treatments that repair damaged tissues and restore the body to its original health. Our Hub will play a role in the development of these treatments and thereby help to build a strong UK industry that makes a worldwide impact. We are particularly interested in the methods by which these new treatments are administered to patients. It is difficult to deliver a living cell as a medicine because these cells are fragile and will not form tissue if they experience adverse conditions. We will invent methods to deliver cells to the correct part of the body in an optimal state to repair tissue. Our Hub will create new materials and technologies that can be used in a very large number of future medical applications. In the first phase of our work we will design new materials that recreate the opitmal conditions for stem cells to form tissue. Next we will work with 7 teams who are directly involved in translating new scientific breakthroughs into new medicines. These teams will test our materials and help improve their design by initial studies of suitability for use in Parkinson's Disease, liver diseases, bone repair, skin wound regeneration, cartilage repair, treatments of oesophageal cancer and to assist in anterior cruciate ligament operations.We are working with leading UK industry to ensure that our technologies can be taken forward as new products that originate in the UK but treat patients across the World.

再生医学将在未来30年内改变人类健康。我们有能力创造新的治疗方法，修复受损的组织，恢复身体原有的健康。我们的中心将在这些治疗的发展中发挥作用，从而帮助建立一个强大的英国产业，使世界范围内的影响。我们特别感兴趣的是这些新的治疗方法给病人。很难将活细胞作为药物输送，因为这些细胞很脆弱，如果它们经历不利条件，就不会形成组织。我们将发明将细胞以最佳状态输送到身体正确部位以修复组织的方法。我们的中心将创造新的材料和技术，可用于未来大量的医疗应用。在我们工作的第一阶段，我们将设计新材料，重新创造干细胞形成组织的最佳条件。接下来，我们将与7个直接参与将新的科学突破转化为新药的团队合作。这些团队将测试我们的材料，并通过初步研究适用于帕金森病，肝病，骨修复，皮肤伤口再生，软骨修复，我们正在与英国领先的行业合作，以确保我们的技术可以作为新产品向前发展，这些产品起源于英国，但却可以治疗英国的患者。世界

项目成果

Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics.

• DOI: 10.1021/acsnano.6b07607
• 发表时间: 2017-01-24
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Armstrong JP;Holme MN;Stevens MM
• 通讯作者: Stevens MM

Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning.

• DOI: 10.1002/adma.201802649
• 发表时间: 2018-10
• 期刊: Advanced materials (Deerfield Beach, Fla.)
• 作者: Armstrong JPK;Puetzer JL;Serio A;Guex AG;Kapnisi M;Breant A;Zong Y;Assal V;Skaalure SC;King O;Murty T;Meinert C;Franklin AC;Bassindale PG;Nichols MK;Terracciano CM;Hutmacher DW;Drinkwater BW;Klein TJ;Perriman AW;Stevens MM
• 通讯作者: Stevens MM

The effect of injection using narrow-bore needles on mammalian cells: administration and formulation considerations for cell therapies.

• DOI: 10.1111/jphp.12362
• 发表时间: 2015-05
• 期刊: The Journal of pharmacy and pharmacology
• 作者: Amer MH;White LJ;Shakesheff KM
• 通讯作者: Shakesheff KM

Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage.

• DOI: 10.1038/s41536-018-0042-7
• 发表时间: 2018
• 期刊: NPJ Regenerative medicine
• 影响因子: 7.2
• 作者: Albro MB;Bergholt MS;St-Pierre JP;Vinals Guitart A;Zlotnick HM;Evita EG;Stevens MM
• 通讯作者: Stevens MM

A biomaterials approach to influence stem cell fate in injectable cell-based therapies.

• DOI: 10.1186/s13287-018-0789-1
• 发表时间: 2018-02-21
• 期刊: Stem cell research & therapy
• 影响因子: 7.5
• 作者: Amer MH;Rose FRAJ;Shakesheff KM;White LJ
• 通讯作者: White LJ