ACTG 152--ZDV 与 DDI 与 DDI AZT 在 HIV 感染儿童中的试验-猫眼课题宝

ACTG 152--ZDV 与 DDI 与 DDI AZT 在 HIV 感染儿童中的试验

批准号：

5218217

负责人：

JOHN LAMBERT

金额：

$0.0万

依托单位：

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/5218217

关键词：

2'3' dideoxyinosine AIDS therapy HIV infections child (0-11) clinical research combination chemotherapy drug screening /evaluation human subject human therapy evaluation pediatric AIDS pediatric pharmacology zidovudine

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中文摘要

翻译

actg152：一项齐多夫定（ZDV）与

英文摘要

ACTG 152:, a randomized comparative trial of Zidovudine (ZDV) versus didanosine (ddI) versus ZDV plus ddI in symptomatic HIV-infected patients, has enrolled fifteen patients. This is an important trial which gives direct comparison of the only licensed antiretroviral drugs for children, both alone and in combination. This study ended in Fall of 1995, and it has been found that AZT is less optimal than either ddI or ddI+AZT, and has helped change the standard of care for children with HIV. Among our patients, two have been dropped from study because of poor compliance. This illustrates the recurrent theme of the impact of HIV-infection on families, ill health, psychological stress, and frequently other high risk behaviors by parents--all of which adversely affect the ability of the family to care for their infected children.

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