TRPM3 regulation of chronic pain

TRPM3 对慢性疼痛的调节

• 批准号: MR/L010747/1
• 负责人: Stuart Bevan
• 金额: $ 73.82万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL010747%2F1
• 关键词: TRPM3; regulation; chronic; pain

Chronic pain is a major problem for up to 19% of the people and with the increasing age of the population the number is likely to increase. Currently the medicines available either do not relieve the pain adequately in a large percentage of patients or have undesirable side effects such as drowsiness or stomach discomfort and ulcers. We have discovered that an ion channel protein expressed by sensory nerves and in other areas in the nervous system plays an important role in the development of persistent pain associated with either nerve injury or inflammation. This is relevant for many human painful conditions associated with arthritis, shingles, back problems and surgery. Using mice where we can selectively delete the protein from different parts of the nervous system we will find out if the important site of action is in the peripheral sensory nerves, the spinal cord or the brain. We will also find out if inhibiting the function of this protein can reverse chronic pain once it has developed which will be important property for any new medicine that could be developed from our research. We will also find out how this protein operates to control pain. This will be important for an understanding of how the protein fits in with the other processes that operate in the nervous system and will aid us in developing new treatment for pain.

慢性疼痛是19%的人的主要问题，随着人口年龄的增长，这个数字可能会增加。目前可用的药物要么不能充分缓解大部分患者的疼痛，要么有不良副作用，如嗜睡或胃部不适和溃疡。我们发现由感觉神经和神经系统其他区域表达的离子通道蛋白在与神经损伤或炎症相关的持续性疼痛的发展中起重要作用。这与许多与关节炎、带状疱疹、背部问题和手术有关的人类疼痛状况有关。在老鼠身上，我们可以选择性地从神经系统的不同部分删除蛋白质，我们将发现重要的作用部位是在周围感觉神经，脊髓还是大脑。我们还将发现抑制这种蛋白质的功能是否可以逆转慢性疼痛，一旦它发展起来，这将是从我们的研究中开发的任何新药的重要特性。我们还将发现这种蛋白质是如何控制疼痛的。这对于理解蛋白质如何与神经系统中的其他过程相适应非常重要，并将帮助我们开发新的疼痛治疗方法。

项目成果

Topical Oxaliplatin Produces Gain- and Loss-of-Function in Multiple Classes of Sensory Afferents

• DOI: 10.1016/j.jpain.2023.07.023
• 发表时间: 2023-12-12
• 期刊: JOURNAL OF PAIN
• 影响因子: 4
• 作者: Saleque，Nurjahan;Vastani，Nisha;Bevan，Stuart
• 通讯作者: Bevan，Stuart

Autoantibodies produce pain in complex regional pain syndrome by sensitizing nociceptors

• DOI: 10.1097/j.pain.0000000000001662
• 发表时间: 2019-12-01
• 期刊: PAIN
• 影响因子: 7.4
• 作者: Cuhadar, Ulku;Gentry, Clive;Andersson, David A.
• 通讯作者: Andersson, David A.