PHASE II/III DOUBLE BLIND STUDY OF AMITRIPTYLINE AND MEXILETINE--HIV INFECTION

阿米替林和美西律的 II/III 期双盲研究——HIV 感染

• 批准号: 5218952
• 负责人: HENRY S SACKS
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218952
• 关键词: AIDS therapy; HIV infections; amitriptyline; analgesics; clinical research; combination chemotherapy; drug screening /evaluation; human subject; human therapy evaluation; nervous system disorder chemotherapy; pain; pain threshold

The primary objective of this study is to assess the effectiveness of amitriptyline and mexiletine in reducing pain intensity in patients with HIV-related painful neuropathy, as measured by the pain intensity description scale developed by Gracely et al. The study will also assess the safety and tolerability of study treatments.

本研究的主要目的是评估 阿米替林和美西律在减轻患者疼痛强度方面的作用 HIV 相关的疼痛性神经病，通过疼痛强度来衡量 Gracely 等人开发的描述量表。 该研究还将评估 研究治疗的安全性和耐受性。