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FRUCTOSE-INDUCED METABOLIC ABNORMALITIES OF THE RENAL TUBULE IN HFI

FRUCTOSE-INDUCED METABOLIC ABNORMALITIES OF THE RENAL TUBULE IN HFI
HFI 中果糖引起的肾小管代谢异常
批准号:
5219053
负责人:
R C MORRIS
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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中文摘要
翻译
这种疾病是由基因缺陷醛缩酶B引起的
英文摘要
This disease is caused by a genetically defective aldolase B, which in the kidney occurs only in the proximal tubule. Dr. Morris's group has shown that phosphate loading mitigates the renal transepithelial transport dysfunction induced by fructose, presumably by the fructose induced fall in intracellular levels of ATP, while increasing the urinary excretion of N-acetylglucosaminidase.
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