SALT SENSITIVITY IN NORMOTENSIVE AFRICAN AMERICANS

[摘要]具体目的：在血压正常的非裔美国人中，我们将确定：7在血压正常的黑人中是否会诱发盐敏感现象，这分别取决于饮食中钾的摄入量是轻度缺乏还是高正常。是否血压正常的盐敏感现象与肾血流动力学紊乱有关，其特征是滤过率增加，当正常高钾饮食摄入阻止盐敏感表达时，是否可以预防这种增加。是否对盐敏感：a)饮食负荷柠檬酸钠引起升压反应或肾血流动力学紊乱；b)日粮中Cl-的负荷增加了NaCl负荷引起的肾血流动力学紊乱的任何部分。交感神经应激是否增强了盐敏感性或相关肾血流动力学安排的任何部分，以及饮食中的钾是否调节了这种增强。无论在盐敏感的人群中，饮食中的钾都能调节盐诱导的微量白蛋白尿。

[Abstract not provided by PI] SPECIFIC AIMS In normotensive African-Americans, we will determine: 7 Whether the phenomenon of salt-sensitivity is or is not evoked in normotensive blacks, depending on whether the dietary intake of potassium is marginally deficient or high-normal, respectively. 7 Whether the phenomenon of normotensive salt-sensitivity is associated with a renal hemodynamic derangement that is characterized by an increased filtration fraction and whether that increase is prevented when a high-normal dietary intake of potassium prevents expression of salt-sensitivity. 7 Whether in those who are salt-sensitive: a) dietary loading of sodium citrate elicits either a pressor response or renal hemodynamic derangement; and b) dietary loading of Cl- as KCl augments any part of the renal hemodynamic derangement induced by NaCl loading. 7 Whether sympathetic stress augments either salt-sensitivity or any part of the associated renal hemodynamic arrangement, and whether dietary potassium modulates any such augmentation.. 7 Whether in those who are salt-sensitive, dietary potassium modulates salt-induced microalbuminuria.