BETA-ADRENERGIC RECEPTOR STRUCTURE AND FUNCTION

β-肾上腺素能受体结构和功能

• 批准号: 5220302
• 负责人: STEVEN B KELSEN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5220302
• 关键词: adenylate cyclase; beta adrenergic receptor; clinical research; human subject; immunoregulation; inflammation; laboratory rabbit; protein structure function; receptor coupling; respiratory epithelium; respiratory hypersensitivity

Stimulation of beta-adrenergic receptors (B-AR) on the tracheobronchial epithelium elicits a variety of cellular responses which affect the defense of the respiratory tract and which may alter the intensity of the inflammatory response in the airway. The objectives of this proposal are to characterize the B-AR coupled adenyly cyclase system in isolated tracheobronchial epithelial cells obtained from rabbits and humans. These studies should help elucidate the mechanisms regulating the B-AR-coupled adenylyl cyclase system.

β-肾上腺素能受体(B-AR)对气管、支气管壁的刺激 上皮会引起多种细胞反应，从而影响 呼吸道的防御，并可能改变呼吸道的强度 呼吸道的炎症反应。这项提议的目标是 B-AR偶联的腺苷环化酶系统的特性 取自兔和人的气管、支气管上皮细胞。 这些研究应该有助于阐明调节 B-AR偶联的腺酰环化酶系统。