CHROMOSOMAL MAPPING OF THE LOCUS FOR CONGENITAL NEPHROTIC SYNDROME (CNF)

本项目旨在确定先天性肾病的发病部位， 在北美家庭中的芬兰型综合征。 我们的第一个目标 是确定这些家族中的疾病基因座是否映射到19 q， 在芬兰CNF家族中已定位了疾病位点。 最终，我们打算确定基因座并描述突变 在每个家庭。 在两个家庭中，疾病位点已被定位到 19 q. 第三个家庭的研究正在进行中;第四个家庭是 在采集血液的过程中

This project aims to identify the disease locus for congenital nephrotic syndrome of the Finnish type in North American families. Our first goal is to determine whether the disease locus in these families maps to 19q, where the disease locus has been mapped in Finnish CNF families. Ultimately we intend to identify the locus and characterize the mutation in each family. In two families the disease locus has been mapped to 19q. Studies are in progress in the third family; the fourth family is in the process of having blood collected.