CHROMOSOMAL MAPPING OF THE LOCUS FOR CONGENITAL NEPHROTIC SYNDROME (CNF)

本项目旨在确定先天性肾病的病源地。 北美家庭中的芬兰型综合症。我们的第一个目标 是为了确定这些家族中的疾病基因是否映射到19q， 在芬兰CNF家庭中已绘制出该疾病基因座的地图。 最终，我们打算确定该基因座并确定突变的特征 在每个家庭里。在两个家系中，疾病基因已被映射到 19q.第三个家庭正在进行研究；第四个家庭是 在采集血液的过程中。

This project aims to identify the disease locus for congenital nephrotic syndrome of the Finnish type in North American families. Our first goal is to determine whether the disease locus in these families maps to 19q, where the disease locus has been mapped in Finnish CNF families. Ultimately we intend to identify the locus and characterize the mutation in each family. In two families the disease locus has been mapped to 19q. Studies are in progress in the third family; the fourth family is in the process of having blood collected.