BIOCHEMICAL ASPECTS OF SUICIDAL BEHAVIOR

自杀行为的生化方面

• 批准号: 5220972
• 负责人: MICHAEL STANLEY
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5220972
• 关键词: behavioral genetics; cerebrospinal fluid; clinical research; human subject; neurochemistry; neurotransmitter metabolism; self destructive behavior; serotonin; suicide

This study will assess the hypothesis that persons in suicidal crisis possess altered serotonin metabolism as indicated by reduced CSF 5-HIAA. A parallel groups design will measure CSF 5-HIAA levels in subjects with recent suicide attempts and after amelioration of the suicidal crisis. CSF 5-HIAA levels will be compared to normal controls, self-mutilators, and trichotillomaniacs. Correlation with other biochemical indices and genetic components will be explored.

本研究将评估处于自杀危机中的人 5-羟色胺代谢改变，表现为CSF 5-HIAA降低。 平行组设计将测量患有以下疾病的受试者的CSF 5-HIAA水平： 近期自杀未遂和自杀危机改善后。 将CSF 5-HIAA水平与正常对照、自残者、 和色情狂与其他生化指标的相关性， 将对遗传成分进行研究。