Sleep, breathing, hemodynamic oscillations, and cerebrospinal fluid movements - Building toward a novel treatment approach for Alzheimer's disease

睡眠、呼吸、血流动力学振荡和脑脊液运动——构建阿尔茨海默病的新型治疗方法

• 批准号: 10740443
• 负责人: AMY J SCHWICHTENBERG
• 金额: $ 19万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740443
• 关键词: Adult; Alzheimer' s Disease; American; Amyloid beta-Protein; Animals; Behavior; Biological; Blood; Blood Circulation; Brain; Breathing; Cardiac; Cerebrospinal Fluid; Cerebrovascular Circulation; Circulation; Clinical Trials; Coupled; Coupling; Cues; Diagnosis; Frequencies; Functional Magnetic Resonance Imaging; Goals; Human; Individual; Intervention; Knowledge; Link; Measures; Meditation; Movement; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Outcome; Participant; Pathology; Pathway interactions; Pattern; Physiological; Physiological Processes; Pilot Projects; Process; Quality of life; Research; Respiration; Sampling; Scanning; Signal Transduction; Sleep; Sleep Deprivation; Sleep Disorders; Sleep Stages; Slow-Wave Sleep; System; Testing; Tissues; Variant; Visual; Wakefulness; Work; abeta accumulation; awake; cerebral blood volume; cranium; fluid flow; glymphatic system; hemodynamics; high reward; improved; individual variation; magnetic resonance imaging/electroencephalography; middle age; non rapid eye movement; novel; pressure; tau Proteins; wasting

Sleep, breathing, hemodynamic oscillations, and cerebrospinal fluid movements – Building toward a novel treatment approach for Alzheimer's disease Sleep deficiencies/problems are common in Alzheimer's disease with several hypothesized connections to the movement of cerebral spinal fluid (CSF) in the brain. For example, within Alzheimer's disease the accumulation of beta-amyloid and tau proteins may reflect inefficiencies in neuro-metabolic waste clearance during sleep (a glymphatic system process that is intricately linked with CSF movement). Within neurodegenerative research, the circulation of CSF has hypothesized links to several biological/physiological processes (e.g., sleep, hemodynamic oscillations, breathing); however, we are limited in our understanding of how to potentially improve CSF movement and neuro-metabolic waste clearance to ultimately slow the progression of Alzheimer's disease. The present study fills these critical gaps by (1) quantifying sleep-coupled CSF movement and (2) documenting how CSF movement is coupled with other (more easily assessed and manipulated) biological signals (i.e., hemodynamic oscillations, breathing). The overarching goals of this line of work are to improve our understanding of CSF movement and how this knowledge can be leveraged to slow the progression of Alzheimer's disease. Unlike blood circulation, CSF has no `engine' to drive its flow; therefore, changes in cerebral blood volume (CBV) likely serve as a `driver' of CSF movement. Previous research demonstrates that increases in CBV can be neuronally driven (e.g., sleep); arterial pulsation driven; or breath driven (e.g., meditation/guided breathing). However, we do not understand the magnitude of these changes/couplings. Improving CSF movement/circulation for individuals with Alzheimer's disease has the potential to slow the pathology progression and could prolong higher quality of life for the millions of Americans currently diagnosed.  Aim 1: Assess the degree of coupling between cerebral blood volume (CBV) and cerebral spinal fluid (CSF) movement during wake and sleep states.  Aim 2: Assess the relative contributions of breathing oscillations on CBV and CSF fluctuations during wake and sleep states.

睡眠、呼吸、血流动力学振荡和脑脊液运动——朝a方向发展