GENTAMICIN PHARMACOKINETICS IN THE NEONATE

该项目将使用一室药代动力学模型来预测 庆大霉素在新生儿中的高峰和低谷。如果这项研究的结果 可以一致地将特定变量关联在一起，例如窒息或 呼吸窘迫综合征，随着庆大霉素清除量的变化 新生儿，它会允许更合适的配方 建议使用庆大霉素治疗，并将降低发病率 新生婴儿血液中的毒性和亚治疗水平。

This project will use a one compartment pharmacokinetic model to predict gentamicin peaks and troughs in neonates. If the results of this study can consistently correlate particular variables, such as asphyxia or respiratory distress syndrome, with changing gentamicin clearance in the neonate, it would allow the formulation of more appropriate recommendations for gentamicin therapy, and would decrease the incidence of both toxic and subtherapeutic blood levels in newborn babies.