Developing microenvironment-based prognostic biomarkers for early breast cancer

开发基于微环境的早期乳腺癌预后生物标志物

• 批准号: nhmrc : 2005218
• 金额: $ 13.27万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developing-microenvironment-based-breast-cancer/1780509
• 关键词: Developing; microenvironment; based; prognostic; biomarkers

Approximately 20% of breast cancer patients are now diagnosed with ductal carcinoma in situ (DCIS), an early stage where tumour cells are confined within the ducts of the breast and pose no threat to life. Once cells spread beyond the duct into surrounding breast tissue, risk of spread increases dramatically. This project aims to use a unique set of patient samples to identify markers that predict DCIS patients that are most at risk of spread, to personalise therapy to and reduce over-treatment.

大约20%的乳腺癌患者现在被诊断为导管原位癌（DCIS），这是一个早期阶段，肿瘤细胞被限制在乳腺导管内，不会对生命构成威胁。一旦细胞扩散到导管外进入周围的乳腺组织，扩散的风险就会急剧增加。该项目旨在使用一组独特的患者样本来识别预测DCIS患者的标志物，这些患者最有可能扩散，以个性化治疗并减少过度治疗。