ORION: Oncology Research Integration using OHDSI-based NLP (NCI Cancer Informatics Scholar)

项目摘要 赫伯特欧文综合癌症中心（CDC）被指定为国家癌症研究所 (NCI)1972年在癌症中心，并于1979年获得综合地位。该委员会是关键的驱动力， 癌症科学研究、临床试验、创新患者护理、癌症教育和培训以及社区 在哥伦比亚大学的欧文医疗中心（CUIMC）和纽约长老会医院（NYPH）外展。 在本项目期间（2014年至今），CUIMC和NYPH承诺为以下项目提供4.15亿美元：（1） 基础、转化、临床和人口科学领域的新研究计划，拥有超过50名战略教师 （2）为实验室研究、干台研究和临床活动新建和扩建设施; (3)主要的教师招聘;和，（4）支持的CIMCC的行政核心。一个主要方面是， 招聘Anil K. Rustgi，MD在2018年底担任PECC主任。Rustgi拥有明确的权力， 癌症研究空间和癌症护理设施，并通过 变革性的欧文家庭信托礼物，通过他作为肿瘤学副院长的双重角色进一步加强 （CUIMC）和癌症服务主任（NYPH）。在这个项目期间， 促进科学研究结构调整的跨学科交叉科学主题 项目包括来自34个部门和6个学校的175名成员：癌症基因组学和 表观基因组学;肿瘤生物学和微环境;精确肿瘤学和系统生物学;和，癌症 人口科学重要的是，Rustgi创建了致力于社区外展和参与的单位 (COE)和癌症研究职业发展（CRCE），并加强了12个共享资源。的 研究计划产生了有影响力的科学，发表了3，399篇论文，其中626篇是内部论文。 456个是方案间的。NCI资金总额为2600万美元，癌症相关资金为 九千二百万项目协调委员会要求CCSG为下一个项目期提供每年410万美元的支助（DC总额）。

PROJECT SUMMARY The Herbert Irving Comprehensive Cancer Center (HICCC) was designated as a National Cancer Institute (NCI) Cancer Center in 1972 and gained comprehensive status in 1979. The HICCC is the critical driver of cancer scientific research, clinical trials, innovative patient care, cancer education and training and community outreach at Columbia University's Irving Medical Center (CUIMC) and NewYork-Presbyterian Hospital (NYPH). During the current project period (2014-present), CUIMC and NYPH committed $415M for the following: (1) new research initiatives in basic, translational, clinical and population sciences with >50 strategic faculty recruitments; (2) new and expanded facilities for laboratory research, dry bench research and clinical activities; (3) major faculty recruitments; and, (4) support of the HICCC's administrative core. A major aspect was the recruitment of Anil K. Rustgi, MD as the HICCC Director in late 2018. Rustgi has the unequivocal authority over cancer research space and cancer care facilities and accompanying substantial resources through the transformative Irving Family Trust Gift, further reinforced through his dual roles as Associate Dean of Oncology (CUIMC) and Chief of Cancer Services (NYPH). Over this project period, there was a greater focus upon transdisciplinary cross-cutting scientific themes that catalyzed the restructuring of the scientific research programs encompassing 175 members from 34 Departments and six Schools: Cancer Genomics and Epigenomics; Tumor Biology and Microenvironment; Precision Oncology and Systems Biology; and, Cancer Population Science. Importantly, Rustgi created units dedicated to Community Outreach and Engagement (COE) and Cancer Research Career Enhancement (CRCE) and enhanced the 12 Shared Resources. The Research Programs engendered impactful science with 3,399 publications of which 626 were intra- programmatic and 456 were inter-programmatic. Total NCI funding is $26M and cancer-relevant funding is $92M. The HICCC is requesting CCSG support of $4.1M per year (total DC) for the next project period.