Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles

股骨是一种轻质结构，旨在为生活中的最佳表现而设计。然而，复杂的组织结构、微结构组织及其复杂的加载方案使人们很难理解股骨如何变形和骨折。该项目通过对股骨近端进行微观细节建模来研究股骨骨折。同步加速器股骨图像是在加载和卸载条件下拍摄的。测量皮质应变和骨折，复制可能的多轴载荷。将使用微观有限元模型来研究骨组织结构、组织结构和活动类型对骨折的贡献。由此产生的知识将在未来的矫形外科中应用。

The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotron femur images are taken in loaded and unloaded conditions. Cortical strain and fracture are measured, replicating possible multiaxial loads. Micro finite-element models will be used to study the contribution that the bone tissue architecture, tissue structure and activity types make to the fracture. The resulting knowledge will have future orthopaedic applications.