Regulating protein translation to protect from UV-induced damage

皮肤是保护我们的身体免受外部环境影响的屏障，但长期暴露在紫外线(UV)下会导致皮肤发炎、衰老和癌症。皮肤表皮的维持是紧密平衡的，并由干细胞控制，干细胞在产生后代(分化)的同时持续维持其种群(自我更新)。皮肤干细胞是在发育过程中建立起来的，并在成年后保留下来，允许身体替换、恢复和再生死亡、受损或患病的表皮细胞。我们的研究计划旨在(I)分析表皮干细胞对紫外线照射下皮肤再生的特定贡献，以及(Ii)识别促进细胞在紫外线损伤下存活的新的内在关键因素。我们的研究将改善我们目前对如何维持健康皮肤的理解，并将导致新的发现，对再生医学，特别是对皮肤修复、衰老和癌症具有重要意义。

Skin is the barrier that protects our body against the external environment, but chronic exposure to ultraviolet (UV) light causes skin inflammation, aging and cancer. The maintenance of the skin epidermis is tightly balanced and controlled by stem cells that continuously maintain their population (self-renewal) while generating progeny (differentiation). Skin stem cells are established during development and are retained in adulthood allowing the body to replace, restore and regenerate dead, damaged or diseased epidermal cells. Our research plan is designed to (i) analyze the specific contribution of epidermal stem cell to regenerate UV-exposed skin and (ii) identify novel intrinsic key factors that promote cell survival in response to UV-damage. Our research will improve our current understanding of how a healthy skin is maintained and will lead to novel discoveries with important implications for regenerative medicine in particular for skin repair, aging and cancer.