Regulating protein translation to protect from UV-induced damage

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Skin is the barrier that protects our body against the external environment, but chronic exposure to ultraviolet (UV) light causes skin inflammation, aging and cancer. The maintenance of the skin epidermis is tightly balanced and controlled by stem cells that continuously maintain their population (self-renewal) while generating progeny (differentiation). Skin stem cells are established during development and are retained in adulthood allowing the body to replace, restore and regenerate dead, damaged or diseased epidermal cells. Our research plan is designed to (i) analyze the specific contribution of epidermal stem cell to regenerate UV-exposed skin and (ii) identify novel intrinsic key factors that promote cell survival in response to UV-damage. Our research will improve our current understanding of how a healthy skin is maintained and will lead to novel discoveries with important implications for regenerative medicine in particular for skin repair, aging and cancer.