NALTROXENE VS PROPRANOLOL FOR TREATMENT OF BEHAVIOR IN AUTISTIC CHILDREN

纳曲烯与普萘洛尔治疗自闭症儿童行为的比较

• 批准号: 5225494
• 负责人: MICHELLE KLEIMAN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5225494
• 关键词: aggression; autism; behavior modification; child (0-11); clinical research; human subject; human therapy evaluation; longitudinal human study; mental disorder chemotherapy; naltrexone; propranolol; self destructive behavior

Six patients have been enrolled, and three have completed the study. The other three patients were discontinued in the study due to lack of observable aggressive and/or self-injurious behaviors seen during baseline videotaping sessions. Of the three patients that have completed the study-two showed differential response across medications and conditions-both were treated with the more effective medication at the conclusion of the study. The other patient showed differential response across conditions only-and no significant response to the medication. He was treated with a different (non-study) medication, at the conclusion of the study. We plan to continue enrolling another ten patients over the next 1-2 years to determine the most effective treatment(s) for this patient population.

六名患者已入学，三名患者已经完成了这项研究。这 由于缺乏 可观察到的侵略性和/或自我伤害行为 基线录像会议。在完成的三名患者中 研究两家在药物之间显示出差异反应， 在疾病中用更有效的药物治疗 该研究的结论。另一名患者显示出差异反应 在范围内，只有对药物的重大反应。他 结论是用不同（非研究）药物治疗的 研究。我们计划继续在其他十名患者中注册 接下来的1 - 2年来确定最有效的治疗方法 患者人数。