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NEUTROPHILS, CYTOKINES AND CYTOKINE RECEPTORS IN SEPTIC SHOCK

NEUTROPHILS, CYTOKINES AND CYTOKINE RECEPTORS IN SEPTIC SHOCK
感染性休克中的中性粒细胞、细胞因子和细胞因子受体
批准号:
5225555
负责人:
Charles Emory McCall
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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英文摘要
Human polymorphonuclear leukocytes (PMNL) synthesize, secrete, and contain specific membrane receptors for, and respond to, the cytokines II-1 alpha and beta and TNF-beta. Both of these cytokines and PMNL play an essential role in the pathogenesis of acute disseminated inflammation with organ failure which may follow microbial infection (septic shock). Dr. McCall's objective is to show that septic shock in humans is consistently associated with amplified expression of the IL-1 beta gene.
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Redox control over metabolism and mitochondrial bioenergetics directs the course of acute inflammation and sepsis
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