ERA-NET NEURON: Identification and study of different immune cell populations and their role in chronic pain

ERA-NET NEURON：不同免疫细胞群的识别和研究及其在慢性疼痛中的作用

• 批准号: MR/M501785/1
• 负责人: Stephen McMahon
• 金额: $ 44.24万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM501785%2F1
• 关键词: ERA; NET; NEURON; Identification; study

About one in five individuals is likely to suffer from chronic pain in their lifetime. Many diseases andconditions can cause intractable pain, for instance rheumatoid arthritis or nerve damage caused byinjury or virus-infection, and these pains frequently have devastating consequences. While scientistshave yet to identify fool-proof treatment options, they have made some important advances inunderstanding what goes wrong in the body of a chronic pain sufferer. In particular, we now know thatthe way our immune system responds to injury or infection can have an important impact on chronicpain. What is less clear, is which cell types are involved exactly and what it is about their responsesthat is so damaging to the surrounding neurons. Could the nature of this immune response predispose people towards developing chronic pain?In this grant, we would like to investigate these questions further. We will use new experimentalmethods to isolate immune cells and study their molecular responses. We will also study patientssuffering from acute pain to identify whether their immune response makes them more or less likely todevelop persistent pain. Our experiments have the potential to identify risk factors for chronic pain as well as novel avenues for treatment.

大约五分之一的人可能在一生中遭受慢性疼痛。许多疾病和病症会导致顽固性疼痛，例如类风湿性关节炎或由损伤或病毒感染引起的神经损伤，这些疼痛通常具有毁灭性的后果。虽然科学家们还没有找到万无一失的治疗方案，但他们在了解慢性疼痛患者的身体出了什么问题方面取得了一些重要进展。特别是，我们现在知道我们的免疫系统对损伤或感染的反应方式对慢性疼痛有重要影响。不太清楚的是，到底是哪种细胞类型参与其中，以及它们的反应是什么对周围的神经元造成了如此大的损害。这种免疫反应的性质是否会使人们容易患上慢性疼痛？在这篇文章中，我们想进一步研究这些问题。我们将使用新的实验方法来分离免疫细胞并研究它们的分子反应。我们还将研究急性疼痛患者，以确定他们的免疫反应是否使他们更容易或更不容易发展为持续性疼痛。我们的实验有可能确定慢性疼痛的危险因素以及新的治疗途径。

项目成果

The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons.

• DOI: 10.3389/fnmol.2017.00304
• 发表时间: 2017
• 期刊: Frontiers in molecular neuroscience
• 影响因子: 4.8
• 作者: Lopes DM;Denk F;McMahon SB
• 通讯作者: McMahon SB

Sex differences in peripheral not central immune responses to pain-inducing injury.

• DOI: 10.1038/s41598-017-16664-z
• 发表时间: 2017-11-28
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Lopes DM;Malek N;Edye M;Jager SB;McMurray S;McMahon SB;Denk F
• 通讯作者: Denk F

Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis.

• DOI: 10.1097/j.pain.0000000000001394
• 发表时间: 2019-01
• 期刊: Pain
• 影响因子: 7.4
• 作者: Fernandez-Zafra T;Gao T;Jurczak A;Sandor K;Hore Z;Agalave NM;Su J;Estelius J;Lampa J;Hokfelt T;Wiesenfeld-Hallin Z;Xu X;Denk F;Svensson CI
• 通讯作者: Svensson CI