LONG TERM MORTALITY OF COMMUNITY AQUIRED PNEUMONIA

社区获得性肺炎(CAP)每年影响400多万人，是美国第六大死因。虽然许多研究已经评估了肺炎的短期死亡率，但关于这种疾病的长期死亡率的研究很少，需要更好地了解CAP患者的长期死亡率，以便医生有准确的知识作为治疗决定的基础，并与患者和家人进行讨论。在这项研究中，我们希望在肺炎患者结局研究团队(PORT)队列研究的基础上，提高我们对CAP患者长期死亡率的理解。肺炎港队列研究是一项为期29个月的前瞻性多中心研究，包括2287名患者，他们在确诊后进行了长达90天的跟踪调查。利用新斯科舍省生命统计局的国家死亡指数和死亡证明数据，我们将在首次诊断出CAP五年后获得死亡信息。我们假设功能状态降低、年龄和合并疾病的负担是CAP患者长期死亡率的独立预测因素。我们将使用单变量和多变量的Cox比例风险模型来确定与长期死亡率相关的自变量。这项研究将为CAP患者的长期预后提供有意义的见解。

DESCRIPTION Community-acquired pneumonia (CAP) affects over four million persons annually, and is the sixth leading cause of death in the United States. Although numerous studies have assessed short-term mortality of Pneumonia, there have been few studies on the long-term mortality of this illness, improved understanding of the long-term mortality of patients with CAP is needed so physicians have accurate knowledge upon which to base treatment decisions and for discussions with patients and families. In this study, we wish to build upon the work of the Pneumonia Patient Outcomes Research Team (PORT) cohort study to improve our understanding of the long-term mortality of patients with CAP. The Pneumonia PORT cohort study was a 29-month, prospective, multi-center of 2287 patients who were followed for up to 90-days post-diagnosis. Using the National Death Index and death certificate data from the Nova Scotia Department of Vital Statistics, we will obtain mortality information five years after the initial diagnosis of CAP. We hypothesize that decreased functional status, age, and burden of comorbid illness are independent predictors of long-term mortality of patients with CAP. We will use univariate and multivariate Cox's proportional hazard modeling to determine the independent variables associated with long-term mortality. This study will provide significant insights into the long-term prognosis of patients with CAP.