LONG TERM MORTALITY OF COMMUNITY AQUIRED PNEUMONIA

社区获得性肺炎的长期死亡率

• 批准号: 6185665
• 负责人: Eric M. Mortensen
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6185665
• 关键词: clinical research; communicable disease transmission; community; human data; human mortality; long term survivor; pneumonia

DESCRIPTION Community-acquired pneumonia (CAP) affects over four million persons annually, and is the sixth leading cause of death in the United States. Although numerous studies have assessed short-term mortality of Pneumonia, there have been few studies on the long-term mortality of this illness, improved understanding of the long-term mortality of patients with CAP is needed so physicians have accurate knowledge upon which to base treatment decisions and for discussions with patients and families. In this study, we wish to build upon the work of the Pneumonia Patient Outcomes Research Team (PORT) cohort study to improve our understanding of the long-term mortality of patients with CAP. The Pneumonia PORT cohort study was a 29-month, prospective, multi-center of 2287 patients who were followed for up to 90-days post-diagnosis. Using the National Death Index and death certificate data from the Nova Scotia Department of Vital Statistics, we will obtain mortality information five years after the initial diagnosis of CAP. We hypothesize that decreased functional status, age, and burden of comorbid illness are independent predictors of long-term mortality of patients with CAP. We will use univariate and multivariate Cox's proportional hazard modeling to determine the independent variables associated with long-term mortality. This study will provide significant insights into the long-term prognosis of patients with CAP.

社区获得性肺炎（CAP）每年影响超过400万人，是美国第六大死亡原因。虽然许多研究已经评估了肺炎的短期死亡率，但很少有关于这种疾病的长期死亡率的研究，需要提高对CAP患者长期死亡率的了解，以便医生有准确的知识来做出治疗决策并与患者和家属进行讨论。在这项研究中，我们希望建立在肺炎患者结局研究小组（PORT）队列研究的基础上，以提高我们对CAP患者长期死亡率的理解。Pneumonia PORT队列研究是一项为期29个月、前瞻性、多中心的研究，共有2287例患者接受了诊断后长达90天的随访。使用国家死亡指数和死亡证明数据从新斯科舍省生命统计部，我们将获得死亡率信息后五年的CAP的初步诊断。我们假设功能状态下降、年龄和共病负担是CAP患者长期死亡率的独立预测因素。我们将使用单变量和多变量考克斯比例风险模型来确定与长期死亡率相关的独立变量。这项研究将为CAP患者的长期预后提供重要的见解。