LONG TERM MORTALITY OF COMMUNITY AQUIRED PNEUMONIA

社区获得性肺炎（CAP）每年影响超过400万人，是美国第六大死亡原因。尽管有许多研究评估了肺炎的短期死亡率，但对这种疾病的长期死亡率的研究很少，因此需要提高对CAP患者长期死亡率的了解，以便医生有准确的知识来制定治疗决策，并与患者和家属进行讨论。在本研究中，我们希望以肺炎患者结局研究小组（PORT）队列研究的工作为基础，提高我们对CAP患者长期死亡率的理解。肺炎PORT队列研究是一项为期29个月的前瞻性多中心研究，2287例患者在诊断后随访90天。利用新斯科舍省生命统计部门的国家死亡指数和死亡证明数据，我们将获得初次诊断CAP五年后的死亡率信息。我们假设功能状态、年龄、和合并症负担是CAP患者长期死亡率的独立预测因素。我们将使用单变量和多变量Cox比例风险模型来确定与长期死亡率相关的自变量。这项研究将为CAP患者的长期预后提供重要的见解。

DESCRIPTION Community-acquired pneumonia (CAP) affects over four million persons annually, and is the sixth leading cause of death in the United States. Although numerous studies have assessed short-term mortality of Pneumonia, there have been few studies on the long-term mortality of this illness, improved understanding of the long-term mortality of patients with CAP is needed so physicians have accurate knowledge upon which to base treatment decisions and for discussions with patients and families. In this study, we wish to build upon the work of the Pneumonia Patient Outcomes Research Team (PORT) cohort study to improve our understanding of the long-term mortality of patients with CAP. The Pneumonia PORT cohort study was a 29-month, prospective, multi-center of 2287 patients who were followed for up to 90-days post-diagnosis. Using the National Death Index and death certificate data from the Nova Scotia Department of Vital Statistics, we will obtain mortality information five years after the initial diagnosis of CAP. We hypothesize that decreased functional status, age, and burden of comorbid illness are independent predictors of long-term mortality of patients with CAP. We will use univariate and multivariate Cox's proportional hazard modeling to determine the independent variables associated with long-term mortality. This study will provide significant insights into the long-term prognosis of patients with CAP.