VISUOSPATIAL PROCESSING IN POSTRHINAL CORTEX

鼻后皮层的视觉空间处理

• 批准号: 2862035
• 负责人: David J Bucci
• 金额: $ 3.17万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2862035
• 关键词: attention; behavior test; behavioral /social science research tag; brain electrical activity; brain mapping; cues; electrophysiology; entorhinal cortex; experimental brain lesion; histochemistry /cytochemistry; laboratory rat; memory; neural information processing; parietal lobe /cortex; space perception; visual perception

Recent anatomical studies have identified a region of cortex in the rat, termed postrhinal cortex, that may be homologous to the parahippocampal cortex of primates. In both monkeys and rats, the primary cortical afferents of this region arise from visual association cortex and visuospatial regions such as posterior parietal cortex, suggesting that this region is involved in visuospatial function. Consistent with this concept are preliminary findings indicating that the postrhinal cortex plays a role in specific aspects of spatial memory as well as visuospatial attention. The goal of the proposed research is to further explore the function of this circuitry in spatial cognition. Neuroanatomical methods will be used to examine in detail the topographical and laminar pattern of visuospatial input to the postrhinal cortex (Specific Aim 1), as well as the intrinsic organization of the visual association, posterior parietal, and postrhinal cortices (Specific Aim 2). Neurophysiological methods will be used to examine the encoding of visuospatial information in postrhinal cortex while rats perform a spatial memory task and a visuospatial precueing task designed to measure attentional function (Specific Aim 3). The proposed experiments will be conducted with the purpose of furthering our understanding of the role of medial temporal lobe structures in cognitive function. Findings from these studies may have direct bearing on the neurobiological bases of cognition in both normal and brain-damage humans.

最近的解剖学研究发现了大鼠的一个皮质区域，称为鼻后皮质，可能与灵长类动物的海马旁皮质同源。 在猴子和大鼠中，该区域的主要皮质传入来自视觉关联皮层和视觉空间区域（例如后顶叶皮层），表明该区域涉及视觉空间功能。 与这一概念一致的是初步发现表明鼻后皮层在空间记忆和视觉空间注意力的特定方面发挥着作用。 本研究的目的是进一步探索该电路在空间认知中的功能。 神经解剖学方法将用于详细检查鼻后皮质视觉空间输入的地形和层状模式（具体目标 1），以及视觉关联、后顶叶和鼻后皮质的内在组织（具体目标 2）。当大鼠执行空间记忆任务和旨在测量注意力功能的视觉空间预提示任务时，将使用神经生理学方法检查鼻后皮层视觉空间信息的编码（具体目标 3）。 进行拟议的实验的目的是进一步了解内侧颞叶结构在认知功能中的作用。 这些研究的结果可能对正常人和脑损伤人类的认知神经生物学基础有直接影响。