Investigating the inter-relationship between diabetes and children's educational achievement.

调查糖尿病与儿童教育成绩之间的相互关系。

• 批准号: MR/N015428/1
• 负责人: Robert French
• 金额: $ 50.3万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN015428%2F1
• 关键词: Investigating; inter; relationship; between; diabetes

Context of researchDiabetes is one of the most common chronic childhood illnesses, affecting 1 in every 700 children. There are two types of diabetes which affect how insulin regulates blood glucose levels. In this application, we focus on Type-1 diabetes which is the most common form in childhood, arising from immune-mediated beta-cell (which produce insulin) destruction. A child with Type-1 diabetes must self-inject insulin to keep blood glucose within acceptable limits, the amount needed varying with what they have eaten and physical activity. Type 1 diabetes is estimated to account for £1 billion in direct costs and £0.9 billion in indirect costs for the UK each year. A better understanding of the processes that affect self-management during childhood will help reduce the need for costly interventions.AimsThe overall aim of the research is to better understand the interrelationship between diabetes (and diabetes management) and the educational experience. We will also explore how the relationships between diabetes and education will be affected by characteristics of the child (e.g. gender), their families (e.g. family structure) and the health services they use (e.g. characteristics of diabetes clinics). To make robust statements about these relationships a second aim must be to utilise the most advanced quantitative methods to make the most of the various datasets available.Methodological objectives1. We will identify and link individuals from different health and education datasets. This allows, for example, to make inference on the effect of glycaemic control (using measures from the National Paediatric Diabetes Audit dataset) on educational outcomes (using linked measures from the national educational database).2. We will also use 'multilevel' modelling techniques which adjust for, and allow us to make inference about the 'groupings' in which the children are nested such as families, schools and diabetes clinics. This includes using multiple measures of health and education for an individual over time.3. Where data are missing we will also use sophisticated techniques to infer what those values may be, as otherwise these individuals would simply be deleted from our analysis.Substantive objectives1. To understand how diabetes affects educational attainment. This includes how health measures like diabetes management affect achievement and also which individual characteristics modify these relationships.2. To understand how diabetes changes the health and educational trajectories of individuals, in particular changes in quality of self-management through major educational and physiological transitions.3. To quantify the effect of key groupings (these include schools, diabetes clinics and families) and their characteristics modify the relationships between health and education.Applications & benefitsThe key findings will relate to how a diagnosis of diabetes and diabetes management affects the school experience. We will disseminate these findings to clinicians through the Brecon Group network of Welsh clinics caring for children with diabetes which has developed over the last eighteen years and established the register all new cases. This will be done through a workshop held at Cardiff University for clinicians, service users, school health representatives and Diabetes Specialist Nurses. It is hoped to give practitioners a better understanding of the effects of diabetes in a context in which the young person will spend a considerable amount of their time and which will have a large impact on the quality of their self-management. We will share our findings with other researchers and policy makers through published articles in specialist journals to help develop both the methodological and substantive aspects of the understanding of the role of education and schools in the treatment of chronic childhood conditions.

糖尿病是最常见的慢性儿童疾病之一，每700名儿童中就有1名患有糖尿病。有两种类型的糖尿病影响胰岛素如何调节血糖水平。在本申请中，我们专注于1型糖尿病，这是儿童最常见的形式，由免疫介导的β细胞（产生胰岛素）破坏引起。患有1型糖尿病的儿童必须自行注射胰岛素，以将血糖保持在可接受的范围内，所需的量因他们的饮食和体力活动而异。据估计，1型糖尿病每年在英国造成10亿英镑的直接成本和9亿英镑的间接成本。更好地了解影响自我管理的过程中，在童年将有助于减少昂贵的interventions.AimsThe总体目标的研究是为了更好地了解糖尿病（和糖尿病管理）和教育经验之间的相互关系。我们还将探讨糖尿病和教育之间的关系将如何受到儿童的特征（例如性别），他们的家庭（例如家庭结构）和他们使用的卫生服务（例如糖尿病诊所的特征）的影响。为了对这些关系做出强有力的陈述，第二个目标必须是利用最先进的定量方法，使大多数不同的数据集可用。我们将从不同的健康和教育数据集中识别和链接个人。例如，这允许对血糖控制（使用来自国家儿科糖尿病审计数据集的测量）对教育结果（使用来自国家教育数据库的链接测量）的影响进行推断。我们还将使用“多层次”建模技术进行调整，并允许我们对儿童嵌套的“分组”进行推断，如家庭，学校和糖尿病诊所。这包括随着时间的推移对个人使用多种健康和教育措施。在数据缺失的情况下，我们还将使用复杂的技术来推断这些价值可能是什么，否则这些个人将直接从我们的分析中删除。实质性目标1。了解糖尿病如何影响教育程度。这包括糖尿病管理等健康措施如何影响成就，以及哪些个人特征会改变这些关系。了解糖尿病如何改变个人的健康和教育轨迹，特别是通过主要的教育和生理转变自我管理质量的变化。为了量化关键群体（包括学校、糖尿病诊所和家庭）的影响及其特征，改变健康和教育之间的关系。应用和益处关键发现将涉及糖尿病诊断和糖尿病管理如何影响学校体验。我们将通过布雷孔集团威尔士诊所网络向临床医生传播这些发现，该网络在过去18年中发展起来，并建立了所有新病例的登记册。这将通过在卡迪夫大学为临床医生、服务用户、学校健康代表和糖尿病专科护士举办的讲习班来完成。希望能让医生更好地了解糖尿病的影响，在这种情况下，年轻人将花费大量的时间，这将对他们的自我管理质量产生很大的影响。我们将通过在专业期刊上发表文章与其他研究人员和政策制定者分享我们的研究结果，以帮助发展对教育和学校在治疗慢性儿童疾病中的作用的理解的方法和实质性方面。

项目成果

Type 1 diabetes mellitus and educational attainment in childhood: a systematic review.

1 型糖尿病和儿童教育程度：系统评价。

• DOI: 10.1136/bmjopen-2019-033215
• 发表时间: 2020
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Oakley NJ

Inequalities in older LGBT people's health and care needs in the United Kingdom: a systematic scoping review.

• DOI: 10.1017/s0144686x19001326
• 发表时间: 2021-03
• 期刊: Ageing and society
• 影响因子: 2.5
• 作者: Kneale D;Henley J;Thomas J;French R
• 通讯作者: French R

Association between type 1 diabetes mellitus and educational attainment in childhood: a systematic review protocol.

• DOI: 10.1136/bmjopen-2018-021893
• 发表时间: 2018-08-30
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Oakley NJ;Kneale D;Mann M;Hilliar M;Tan J;Dayan C;Gregory JW;French R
• 通讯作者: French R

Modeling Heterogeneous Variance-Covariance Components in Two-Level Models

• DOI: 10.3102/1076998614546494
• 发表时间: 2014-10-01
• 期刊: JOURNAL OF EDUCATIONAL AND BEHAVIORAL STATISTICS
• 影响因子: 2.4
• 作者: Leckie, George;French, Robert;Browne, William
• 通讯作者: Browne, William

Conducting sexualities research: an outline of emergent issues and case studies from ten Wellcome-funded projects.

进行性行为研究：十个惠康资助项目的紧急问题和案例研究概述。

• DOI: 10.12688/wellcomeopenres.15283.1
• 发表时间: 2019
• 期刊: Wellcome open research
• 作者: Kneale D