Development of Metabolism Radiotracers to Probe Disease Pathology in Human Subjects with Cancer
开发代谢放射性示踪剂来探测人类癌症受试者的疾病病理学
基本信息
- 批准号:MR/N020782/1
- 负责人:
- 金额:$ 481.25万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2016
- 资助国家:英国
- 起止时间:2016 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Our group is interested in discovery and development of novel radiotracers for probing disease biology. In this quinquenium, we propose a translational programme that aims to develop the next generation of imaging approaches for investigation of disease biology in humans based on metabolism. Imaging using positron emission tomography (PET) remains one of the most direct ways of interrogating molecular mechanisms derailed in many diseases including cancer. PET methods are non-destructive and allow tissue biology to be investigated in the species of interest - the human being - non-invasively without associated sampling errors or tissue alterations that occur with biopsy-based approaches. Availability of appropriate probes and their validation in humans remains the major bottleneck in this field of research. Using cancer as the model, we have over the past five years advanced new probes for PET into human imaging to allow associated molecular mechanisms to be investigated. Of current interest is how tumours reprogramme their metabolism, which is difficult to measure by traditional methods in living organs and tissues. In the coming 5 years we will introduce two new imaging probes into humans and complete work on another. These probes detect how tissues burn fatty acids, store energy in the form of glycogen and make synthesise the precursors for membranes. The connectivity of this programme - chemistry design, automation, regulatory, mathematical modelling, and comparing imaging output to pathology - will allow us to provide the tools for translating our post-genome understanding of reprogrammed tumour metabolism into scientific investigation of diseased tissues in situ in humans, while developing candidate probes with potential for managing patients.
我们的团队对发现和开发用于探测疾病生物学的新型放射性示踪剂感兴趣。在这个五年,我们提出了一个翻译计划,旨在开发下一代的成像方法的基础上,在人类的疾病生物学的调查代谢。使用正电子发射断层扫描(PET)成像仍然是询问包括癌症在内的许多疾病中脱轨的分子机制的最直接方法之一。PET方法是非破坏性的,并且允许在感兴趣的物种(人类)中非侵入性地研究组织生物学,而不会发生与基于活检的方法相关的采样误差或组织改变。合适的探针的可用性及其在人体中的验证仍然是这一研究领域的主要瓶颈。以癌症为模型,在过去的五年中,我们将PET的新探针推进到人类成像中,以研究相关的分子机制。目前感兴趣的是肿瘤如何重新编程其代谢,这是难以通过传统方法在活体器官和组织中测量的。在未来5年内,我们将向人类引入两种新的成像探针,并完成另一种成像探针的工作。这些探针检测组织如何燃烧脂肪酸,以糖原的形式储存能量,并合成膜的前体。该计划的连通性-化学设计,自动化,监管,数学建模以及将成像输出与病理学进行比较-将使我们能够提供工具,将我们对重编程肿瘤代谢的后基因组理解转化为对人类原位病变组织的科学研究,同时开发具有管理患者潜力的候选探针。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms
- DOI:10.1039/d2re00219a
- 发表时间:2022-07-13
- 期刊:
- 影响因子:3.9
- 作者:Barnes, Chris;Nair, Manoj;Allott, Louis
- 通讯作者:Allott, Louis
Positron Emission Tomography Probes for Imaging Cytotoxic Immune Cells.
- DOI:10.3390/pharmaceutics14102040
- 发表时间:2022-09-24
- 期刊:
- 影响因子:5.4
- 作者:Amgheib A;Fu R;Aboagye EO
- 通讯作者:Aboagye EO
[ 18 F]Fluorothymidine(FLT)-PET imaging of thymidine kinase 1 pharmacodynamics in non-small cell lung cancer treated with pemetrexed.
[ 18 F]氟胸苷 (FLT)-PET 成像显示培美曲塞治疗的非小细胞肺癌中胸苷激酶 1 的药效学。
- DOI:10.1200/jco.2022.40.16_suppl.3070
- 发表时间:2022
- 期刊:
- 影响因子:45.3
- 作者:Aravind P
- 通讯作者:Aravind P
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Eric Aboagye其他文献
CT-radiomics to predict recurrence following curative-intent radiotherapy for stage I–III non-small-cell lung cancer
- DOI:
10.1016/j.clon.2022.09.034 - 发表时间:
2022-11-01 - 期刊:
- 影响因子:
- 作者:
Sumeet Hindocha;Thomas Charlton;Kristofer Linton-Reid;Benjamin Hunter;Charleen Chan;Merina Ahmed;Emily Robinson;Matthew Orton;Shahreen Ahmad;Fiona McDonald;Imogen Locke;Danielle Power;Matthew Blackledge;Richard Lee;Eric Aboagye - 通讯作者:
Eric Aboagye
Importance of Quantification for the Analysis of PET Data in Oncology: Review of Current Methods and Trends for the Future
- DOI:
10.1007/s11307-011-0514-2 - 发表时间:
2011-08-13 - 期刊:
- 影响因子:2.500
- 作者:
Giampaolo Tomasi;Federico Turkheimer;Eric Aboagye - 通讯作者:
Eric Aboagye
Resistance to tyrosine kinase-targeted therapy in lung cancer: Autophagy and metabolic changes
- DOI:
10.1016/j.mgene.2018.05.044 - 发表时间:
2018-09-01 - 期刊:
- 影响因子:
- 作者:
Hongde Li;William B. Stokes;Emily Chater;Ewa Rupniewska;Rajat Roy;Francesco A. Mauri;Xinxue Liu;Maciej Kaliszczak;Julian Downward;Eric Aboagye;Huiru Tang;Yulan Wang;Michael J. Seckl;Olivier E. Pardo - 通讯作者:
Olivier E. Pardo
TOP-130-YI Deep learning derived radiomics with advanced machine learning outperforms clinical biomarkers in predicting outcomes after atezolizumab plus bevacizumab for advanced hepatocellular carcinoma
TOP - 130 - YI 在预测阿替利珠单抗联合贝伐珠单抗治疗晚期肝细胞癌后的结果方面,基于深度学习衍生的影像组学结合先进的机器学习优于临床生物标志物
- DOI:
10.1016/s0168-8278(25)01316-9 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:33.000
- 作者:
Mathew Vithayathil;Deniz Koku;Claudia Campani;Jean Charles Nault;Olivier Sutter;Nathalie Ganne-Carrié;Eric Aboagye;Rohini Sharma - 通讯作者:
Rohini Sharma
Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress
- DOI:
10.1186/2049-3002-2-s1-o9 - 发表时间:
2014-05-01 - 期刊:
- 影响因子:5.300
- 作者:
Zachary Schug;Barrie Peck;Dylan Jones;Qifeng Zhang;Israt Alam;Tim Witney;Elizabeth Smethurst;Shaun Grosskurth;Adrian Harris;Susan Critchlow;Eric Aboagye;Michael Wakelam;Almut Schulze;Eyal Gottlieb - 通讯作者:
Eyal Gottlieb
Eric Aboagye的其他文献
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{{ truncateString('Eric Aboagye', 18)}}的其他基金
MICA: DCS - Evaluation of [18F]fluoroethyl triazole labelled [Tyr3]Octreotate analogues for the imaging of neuroendocrine tumours
MICA:DCS - [18F]氟乙基三唑标记的[Tyr3]奥曲酸类似物用于神经内分泌肿瘤成像的评估
- 批准号:
MR/J007986/1 - 财政年份:2013
- 资助金额:
$ 481.25万 - 项目类别:
Research Grant
Improving the radiosynthesis of peptides and antibodies for nuclear imaging of cell surface receptors development and
改善用于细胞表面受体发育和核成像的肽和抗体的放射合成
- 批准号:
MC_EX_G0801762 - 财政年份:2009
- 资助金额:
$ 481.25万 - 项目类别:
Research Grant
相似国自然基金
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